Complete remission in acute myeloid leukaemia with t(8;21) following treatment with G‐CSF: flow cytometric analysis of in vivo and in vitro effects on cell maturation

A 75‐year‐old patient diagnosed as having acute myeloid leukaemia with t(8;21) received G‐CSF alone as induction therapy. Complete remission was achieved following 2 weeks of treatment. Flow cytometric analysis, performed by CD45 technique modified by the introduction of preliminary gating with LDS‐751, confirmed the disappearance of blast cells along with myeloid maturation. Finally, in vitro studies demonstrated that G‐CSF, as compared to other differentiation inducers, was able to induce a striking effect toward neutrophilic differentiation.