Prophylactic effects of ceftriaxone in patients after endoscopic papillosphincterotomy

In thirty patients after EPS and gall extraction for cultivation ceftriaxon in preventive dose 1 g was administered. This group of patients was compared with a group of 30 patients after EPS without preventive administration of antibiotic from clinical and biochemical point of view. Most frequently occurring bacteria in the gall of patients after EPS were Pseudomonas aeruginosa and E. coli. All of the detected bacteria were sufficiently sensitive to ceftriaxon. Preventive effect of ceftriaxon was manifested in statistically significant fall of hyperbilirubinemia and hyperamylasemia 24 hours after EPS (p > 0.05). (Tab. 5, Ref. 8.)