Morphological observation of canine natural killer cells mediated cytotoxicity

The cytotoxic effects of canine NK cells on CL-1 target cells were examined by scanning electron microscopy (SEM). NK cell mediated cytotoxicity on CL-1 target cells was detected by 51Cr release assay. SEM showed that a canine NK cell extended projections to the CL-1 target cell. Furthermore, the su...

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Veröffentlicht in:	Journal of Veterinary Medical Science 1999/07/25, Vol.61(7), pp.835-838
Hauptverfasser:	Nariai Nakada, Y. (Yokohama City Univ. (Japan). School of Medicine), Nariai, K, Kosaka, T, Kuwabara, M, Kiuchi, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocyte Subsets - cytology canine Cell Separation Centrifugation, Zonal CHIEN Cytotoxicity, Immunologic DOGS Female Killer Cells, Natural - cytology Killer Cells, Natural - immunology LINFOCITOS LYMPHOCYTE LYMPHOCYTES Male MICROSCOPIA MICROSCOPIE MICROSCOPY Microscopy, Electron, Scanning PERRO SEM T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology TOXICIDAD TOXICITE TOXICITY
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Zusammenfassung:	The cytotoxic effects of canine NK cells on CL-1 target cells were examined by scanning electron microscopy (SEM). NK cell mediated cytotoxicity on CL-1 target cells was detected by 51Cr release assay. SEM showed that a canine NK cell extended projections to the CL-1 target cell. Furthermore, the surface of CL-1 target cells changed a mesh-like structure. Therefore, the cytotoxic effects of canine NK cells on CL-1 target cells were morphologically demonstrated.
ISSN:	0916-7250 1347-7439
DOI:	10.1292/jvms.61.835