Structure–activity relationship studies of dynorphin A and related peptides

Structure–activity relationship studies of dynorphin A and related peptides

An up-to-date review is presented covering all the available information concerning the isolation, discovery, synthesis, conformation, receptor binding characteristics, pharmacological properties and SAR studies of dynorphin A and related peptides. The potential of dynorphin A and its analogs has ye...

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Veröffentlicht in:Peptides 1998-01, Vol.19 (7), p.1277-1292
Hauptverfasser: Naqvi, T., Haq, W., Mathur, K.B.
Format: Artikel
Sprache:eng
Schlagworte:
Analgesia
Animals
Cardiovascular System - drug effects
Dynorphin A
Dynorphin analogs
Dynorphins - chemistry
Dynorphins - isolation & purification
Dynorphins - metabolism
Dynorphins - pharmacology
Humans
Immune System - drug effects
kappa Opioid receptors
NMDA receptors
Receptors, Opioid, kappa - metabolism
Structure-Activity Relationship
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Beschreibung
Zusammenfassung:An up-to-date review is presented covering all the available information concerning the isolation, discovery, synthesis, conformation, receptor binding characteristics, pharmacological properties and SAR studies of dynorphin A and related peptides. The potential of dynorphin A and its analogs has yet to be fully realized.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(98)00042-4