Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices

We have examined the effects of the recently described heptadecapeptide nocistatin on K +-evoked glutamate release from rat cerebrocortical slices in vitro. In vivo, nocistatin reverses the action of nociceptin. Nocistatin (100 nM, n=7) did not inhibit K +-evoked glutamate release alone. Nociceptin...

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Veröffentlicht in:	European journal of pharmacology 1998-09, Vol.356 (2), p.R1-R3
Hauptverfasser:	Nicol, Beverley, Lambert, David G., Rowbotham, David J., Okuda-Ashitaka, Emiko, Ito, Seiji, Smart, Darren, McKnight, Alexander T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - metabolism Cells, Cultured Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Fundamental and applied biological sciences. Psychology Glutamate release Glutamic Acid - metabolism Nociceptin Nocistatin Opioid Peptides - antagonists & inhibitors Opioid Peptides - pharmacology Rats Rats, Wistar Receptors, Opioid - agonists Vertebrates: nervous system and sense organs
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Zusammenfassung:	We have examined the effects of the recently described heptadecapeptide nocistatin on K +-evoked glutamate release from rat cerebrocortical slices in vitro. In vivo, nocistatin reverses the action of nociceptin. Nocistatin (100 nM, n=7) did not inhibit K +-evoked glutamate release alone. Nociceptin (100 nM) inhibited glutamate release by 51.7±8.3% ( P
ISSN:	0014-2999 1879-0712
DOI:	10.1016/S0014-2999(98)00545-7