The pathogenesis of psoriasis and the mechanism of action of tazarotene

The 3 major features of psoriasis—abnormal differentiation of keratinocytes, hyperproliferation of keratinocytes, and infiltration of inflammatory components into the skin—can be quantified by measuring levels of certain biochemical markers. Psoriasis is associated with upregulation or downregulatio...

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Veröffentlicht in:	Journal of the American Academy of Dermatology 1998-10, Vol.39 (4), p.S129-S133
Hauptverfasser:	Duvic, Madeleine, Asano, Arisa T., Hager, Carina, Mays, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Biomarkers Epidermal Growth Factor - metabolism Humans Keratinocytes - metabolism Keratolytic Agents - pharmacology Nicotinic Acids - pharmacology Psoriasis - metabolism Psoriasis - pathology
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Beschreibung
Zusammenfassung:	The 3 major features of psoriasis—abnormal differentiation of keratinocytes, hyperproliferation of keratinocytes, and infiltration of inflammatory components into the skin—can be quantified by measuring levels of certain biochemical markers. Psoriasis is associated with upregulation or downregulation of several of these markers. Tazarotene helps to normalize the levels of the markers, thereby bringing about clinical improvement. (J Am Acad Dermatol 1998;39:S129-33.)
ISSN:	0190-9622 1097-6787
DOI:	10.1016/S0190-9622(98)70309-3