Effects of β-adrenergic blocking therapy on left ventricular diastolic relaxation properties in patients with dilated cardiomyopathy

The hemodynamic mechanism for the improvement in left ventricle (LV) end-diastolic pressure in cardiomyopathy patients treated with beta-adrenergic blocking agents is controversial. We hypothesized that the salutary effect of this kind of therapy on LV end-diastolic pressure would be indicative of a...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1999-08, Vol.100 (7), p.729-735
Hauptverfasser:	KIM, M. H, DEVLIN, W. H, DAS, S. K, PETRUSHA, J, MONTGOMERY, D, STARLING, M. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Biological and medical sciences Cardiomyopathy, Dilated - drug therapy Cardiomyopathy, Dilated - physiopathology Cardiovascular system Diastole - drug effects Female Heart Rate - drug effects Humans Male Medical sciences Metoprolol - pharmacology Metoprolol - therapeutic use Middle Aged Miscellaneous Muscle Relaxation - drug effects Myocardial Contraction - drug effects Pharmacology. Drug treatments Stroke Volume - drug effects Ventricular Function, Left - drug effects
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Zusammenfassung:	The hemodynamic mechanism for the improvement in left ventricle (LV) end-diastolic pressure in cardiomyopathy patients treated with beta-adrenergic blocking agents is controversial. We hypothesized that the salutary effect of this kind of therapy on LV end-diastolic pressure would be indicative of an improvement in late, passive diastolic relaxation properties. We studied 14 cardiomyopathy patients in normal sinus rhythm with no arteriographic evidence of coronary artery disease and an LV ejection fraction of
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.100.7.729