Heart Rate Variability and Progression of Coronary Atherosclerosis

Low heart rate (HR) variability is associated with increased risk of cardiovascular morbidity and mortality, but the causes and mechanisms of this association are not well known. This prospective study was designed to test the hypothesis that reduced HR variability is related to progression of coron...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1999-08, Vol.19 (8), p.1979-1985
Hauptverfasser:	Huikuri, Heikki V, Jokinen, Vesa, Syvänne, Mikko, Nieminen, Markku S, Airaksinen, K E. Juhani, Ikäheimo, Markku J, Koistinen, Juhani M, Kauma, Heikki, Kesäniemi, Antero Y, Majahalme, Silja, Niemelä, Kari O, Frick, M Heikki
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary Angiography Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - physiopathology Coronary Disease - drug therapy Disease Progression Gemfibrozil - therapeutic use Heart Rate - physiology Humans Male Medical sciences Placebos Regression Analysis
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Beschreibung
Zusammenfassung:	Low heart rate (HR) variability is associated with increased risk of cardiovascular morbidity and mortality, but the causes and mechanisms of this association are not well known. This prospective study was designed to test the hypothesis that reduced HR variability is related to progression of coronary atherosclerosis. Average HR and HR variability were analyzed in 12-hour ambulatory ECG recordings from 265 qualified patients participating in a multicenter study to evaluate the angiographic progression of coronary artery disease in patients with prior coronary artery bypass surgery and low high-density lipoprotein cholesterol concentrations (
ISSN:	1079-5642 1524-4636
DOI:	10.1161/01.atv.19.8.1979