Role of sonic hedgehog in branchiomotor neuron induction in zebrafish
The role of zebrafish hedgehog genes in branchiomotor neuron development was analyzed by examining mutations that affect the expression of the hedgehog genes and by overexpressing these genes in embryos. In cyclops mutants, reduction in sonic hedgehog ( shh) expression, and elimination of tiggy-wink...
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| Veröffentlicht in: | Mechanisms of development 1998-08, Vol.76 (1), p.101-115 |
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| creator | Chandrasekhar, Anand Warren, James T Takahashi, Kana Schauerte, Heike E van Eeden, Fredericus J.M Haffter, Pascal Kuwada, John Y |
| description | The role of zebrafish
hedgehog genes in branchiomotor neuron development was analyzed by examining mutations that affect the expression of the
hedgehog genes and by overexpressing these genes in embryos. In
cyclops mutants, reduction in
sonic hedgehog (
shh) expression, and elimination of
tiggy-winkle hedgehog (
twhh) expression, correlated with reductions in branchiomotor neuron populations. Furthermore, branchiomotor neurons were restored in
cyclops mutants when
shh or
twhh was overexpressed. These results suggest that Shh and/or Twhh play an important role in the induction of branchiomotor neurons in vivo. In
sonic-you (
syu) mutants, where Shh activity was reduced or eliminated due to mutations in
shh, branchiomotor neurons were reduced in number in a rhombomere-specific fashion, but never eliminated. Similarly, spinal motor neurons were reduced, but not eliminated, in
syu mutants. These results demonstrate that Shh is not solely responsible for inducing branchiomotor and spinal motor neurons, and suggest that Shh and Twhh may function as partially redundant signals for motor neuron induction in zebrafish. |
| doi_str_mv | 10.1016/S0925-4773(98)00101-4 |
| format | Article |
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hedgehog genes in branchiomotor neuron development was analyzed by examining mutations that affect the expression of the
hedgehog genes and by overexpressing these genes in embryos. In
cyclops mutants, reduction in
sonic hedgehog (
shh) expression, and elimination of
tiggy-winkle hedgehog (
twhh) expression, correlated with reductions in branchiomotor neuron populations. Furthermore, branchiomotor neurons were restored in
cyclops mutants when
shh or
twhh was overexpressed. These results suggest that Shh and/or Twhh play an important role in the induction of branchiomotor neurons in vivo. In
sonic-you (
syu) mutants, where Shh activity was reduced or eliminated due to mutations in
shh, branchiomotor neurons were reduced in number in a rhombomere-specific fashion, but never eliminated. Similarly, spinal motor neurons were reduced, but not eliminated, in
syu mutants. These results demonstrate that Shh is not solely responsible for inducing branchiomotor and spinal motor neurons, and suggest that Shh and Twhh may function as partially redundant signals for motor neuron induction in zebrafish.</description><identifier>ISSN: 0925-4773</identifier><identifier>EISSN: 1872-6356</identifier><identifier>DOI: 10.1016/S0925-4773(98)00101-4</identifier><identifier>PMID: 9767138</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Branchial Region - innervation ; Branchiomotor neuron ; Cell Nucleus - pathology ; cyclops ; Embryo, Nonmammalian ; Embryonic Induction ; Gene Expression Regulation, Developmental ; Hedgehog Proteins ; Hindbrain ; Intracellular Signaling Peptides and Proteins ; Motor Neurons - physiology ; Mutation ; Nervous System - embryology ; Neurons - physiology ; Proteins - genetics ; Proteins - metabolism ; Rhombencephalon - embryology ; Rhombencephalon - pathology ; Rhombomere ; sonic hedgehog ; sonic-you ; Spinal Cord ; tiggy-winkle hedgehog ; Trans-Activators ; Transforming Growth Factor beta - genetics ; Zebrafish ; Zebrafish - embryology ; Zebrafish Proteins</subject><ispartof>Mechanisms of development, 1998-08, Vol.76 (1), p.101-115</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>Copyright 1998 Elsevier Science Ireland Ltd. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-1d721952bb593892f944f2cc3fef1df0bf9c5181ff804b84cbb6cc8efe9cfa253</citedby><cites>FETCH-LOGICAL-c360t-1d721952bb593892f944f2cc3fef1df0bf9c5181ff804b84cbb6cc8efe9cfa253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0925-4773(98)00101-4$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9767138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chandrasekhar, Anand</creatorcontrib><creatorcontrib>Warren, James T</creatorcontrib><creatorcontrib>Takahashi, Kana</creatorcontrib><creatorcontrib>Schauerte, Heike E</creatorcontrib><creatorcontrib>van Eeden, Fredericus J.M</creatorcontrib><creatorcontrib>Haffter, Pascal</creatorcontrib><creatorcontrib>Kuwada, John Y</creatorcontrib><title>Role of sonic hedgehog in branchiomotor neuron induction in zebrafish</title><title>Mechanisms of development</title><addtitle>Mech Dev</addtitle><description>The role of zebrafish
hedgehog genes in branchiomotor neuron development was analyzed by examining mutations that affect the expression of the
hedgehog genes and by overexpressing these genes in embryos. In
cyclops mutants, reduction in
sonic hedgehog (
shh) expression, and elimination of
tiggy-winkle hedgehog (
twhh) expression, correlated with reductions in branchiomotor neuron populations. Furthermore, branchiomotor neurons were restored in
cyclops mutants when
shh or
twhh was overexpressed. These results suggest that Shh and/or Twhh play an important role in the induction of branchiomotor neurons in vivo. In
sonic-you (
syu) mutants, where Shh activity was reduced or eliminated due to mutations in
shh, branchiomotor neurons were reduced in number in a rhombomere-specific fashion, but never eliminated. Similarly, spinal motor neurons were reduced, but not eliminated, in
syu mutants. These results demonstrate that Shh is not solely responsible for inducing branchiomotor and spinal motor neurons, and suggest that Shh and Twhh may function as partially redundant signals for motor neuron induction in zebrafish.</description><subject>Animals</subject><subject>Branchial Region - innervation</subject><subject>Branchiomotor neuron</subject><subject>Cell Nucleus - pathology</subject><subject>cyclops</subject><subject>Embryo, Nonmammalian</subject><subject>Embryonic Induction</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Hedgehog Proteins</subject><subject>Hindbrain</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Motor Neurons - physiology</subject><subject>Mutation</subject><subject>Nervous System - embryology</subject><subject>Neurons - physiology</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><subject>Rhombencephalon - embryology</subject><subject>Rhombencephalon - pathology</subject><subject>Rhombomere</subject><subject>sonic hedgehog</subject><subject>sonic-you</subject><subject>Spinal Cord</subject><subject>tiggy-winkle hedgehog</subject><subject>Trans-Activators</subject><subject>Transforming Growth Factor beta - genetics</subject><subject>Zebrafish</subject><subject>Zebrafish - embryology</subject><subject>Zebrafish Proteins</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo67r6ExZ6Ej1Uk7ZJk5PIsj5gQfBxDk062Ua6zZq0gv56sw_26mmGmW9mmA-hKcE3BBN2-4ZFRtOiLPMrwa8xjsW0OEJjwsssZTllx2h8QE7RWQifOFKEkREaiZKVJOdjNH91LSTOJMF1VicN1Eto3DKxXaJ81enGupXrnU86GLzrYr0edG-3WfILkTE2NOfoxFRtgIt9nKCPh_n77CldvDw-z-4Xqc4Z7lNSlxkRNFOKipyLzIiiMJnWuQFDaoOVEZoSTozhuFC80EoxrTkYENpUGc0n6HK3d-3d1wChlysbNLRt1YEbgmRCUMpLFkG6A7V3IXgwcu3tqvI_kmC50Se3-uTGjRRcbvXJIs5N9wcGtYL6MLX3Fft3uz7EL78teBm0hU5DbT3oXtbO_nPhD0rrgEo</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Chandrasekhar, Anand</creator><creator>Warren, James T</creator><creator>Takahashi, Kana</creator><creator>Schauerte, Heike E</creator><creator>van Eeden, Fredericus J.M</creator><creator>Haffter, Pascal</creator><creator>Kuwada, John Y</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>Role of sonic hedgehog in branchiomotor neuron induction in zebrafish</title><author>Chandrasekhar, Anand ; Warren, James T ; Takahashi, Kana ; Schauerte, Heike E ; van Eeden, Fredericus J.M ; Haffter, Pascal ; Kuwada, John Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-1d721952bb593892f944f2cc3fef1df0bf9c5181ff804b84cbb6cc8efe9cfa253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Branchial Region - innervation</topic><topic>Branchiomotor neuron</topic><topic>Cell Nucleus - pathology</topic><topic>cyclops</topic><topic>Embryo, Nonmammalian</topic><topic>Embryonic Induction</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Hedgehog Proteins</topic><topic>Hindbrain</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Motor Neurons - physiology</topic><topic>Mutation</topic><topic>Nervous System - embryology</topic><topic>Neurons - physiology</topic><topic>Proteins - genetics</topic><topic>Proteins - metabolism</topic><topic>Rhombencephalon - embryology</topic><topic>Rhombencephalon - pathology</topic><topic>Rhombomere</topic><topic>sonic hedgehog</topic><topic>sonic-you</topic><topic>Spinal Cord</topic><topic>tiggy-winkle hedgehog</topic><topic>Trans-Activators</topic><topic>Transforming Growth Factor beta - genetics</topic><topic>Zebrafish</topic><topic>Zebrafish - embryology</topic><topic>Zebrafish Proteins</topic><toplevel>online_resources</toplevel><creatorcontrib>Chandrasekhar, Anand</creatorcontrib><creatorcontrib>Warren, James T</creatorcontrib><creatorcontrib>Takahashi, Kana</creatorcontrib><creatorcontrib>Schauerte, Heike E</creatorcontrib><creatorcontrib>van Eeden, Fredericus J.M</creatorcontrib><creatorcontrib>Haffter, Pascal</creatorcontrib><creatorcontrib>Kuwada, John Y</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chandrasekhar, Anand</au><au>Warren, James T</au><au>Takahashi, Kana</au><au>Schauerte, Heike E</au><au>van Eeden, Fredericus J.M</au><au>Haffter, Pascal</au><au>Kuwada, John Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of sonic hedgehog in branchiomotor neuron induction in zebrafish</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>76</volume><issue>1</issue><spage>101</spage><epage>115</epage><pages>101-115</pages><issn>0925-4773</issn><eissn>1872-6356</eissn><abstract>The role of zebrafish
hedgehog genes in branchiomotor neuron development was analyzed by examining mutations that affect the expression of the
hedgehog genes and by overexpressing these genes in embryos. In
cyclops mutants, reduction in
sonic hedgehog (
shh) expression, and elimination of
tiggy-winkle hedgehog (
twhh) expression, correlated with reductions in branchiomotor neuron populations. Furthermore, branchiomotor neurons were restored in
cyclops mutants when
shh or
twhh was overexpressed. These results suggest that Shh and/or Twhh play an important role in the induction of branchiomotor neurons in vivo. In
sonic-you (
syu) mutants, where Shh activity was reduced or eliminated due to mutations in
shh, branchiomotor neurons were reduced in number in a rhombomere-specific fashion, but never eliminated. Similarly, spinal motor neurons were reduced, but not eliminated, in
syu mutants. These results demonstrate that Shh is not solely responsible for inducing branchiomotor and spinal motor neurons, and suggest that Shh and Twhh may function as partially redundant signals for motor neuron induction in zebrafish.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>9767138</pmid><doi>10.1016/S0925-4773(98)00101-4</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Branchial Region - innervation Branchiomotor neuron Cell Nucleus - pathology cyclops Embryo, Nonmammalian Embryonic Induction Gene Expression Regulation, Developmental Hedgehog Proteins Hindbrain Intracellular Signaling Peptides and Proteins Motor Neurons - physiology Mutation Nervous System - embryology Neurons - physiology Proteins - genetics Proteins - metabolism Rhombencephalon - embryology Rhombencephalon - pathology Rhombomere sonic hedgehog sonic-you Spinal Cord tiggy-winkle hedgehog Trans-Activators Transforming Growth Factor beta - genetics Zebrafish Zebrafish - embryology Zebrafish Proteins |
| title | Role of sonic hedgehog in branchiomotor neuron induction in zebrafish |
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