Role of the cerebellum in exploration behavior
Compared to +/+ mice, Lurcher (+/Lc) mutant mice whose cerebellar cortex is lacking almost all Purkinje cells and granule cells, exhibit a low level of exploration; this deficit is not due to a low level of activity but to both a decreased motivation to explore a novel environment and to spatial def...
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| Veröffentlicht in: | Brain research 1998-10, Vol.808 (2), p.232-237 |
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| creator | Caston, J Chianale, C Delhaye-Bouchaud, N Mariani, J |
| description | Compared to +/+ mice, Lurcher (+/Lc) mutant mice whose cerebellar cortex is lacking almost all Purkinje cells and granule cells, exhibit a low level of exploration; this deficit is not due to a low level of activity but to both a decreased motivation to explore a novel environment and to spatial deficits. The characteristics of exploration in cerebellectomized +/+ and +/Lc mice suggest that the cerebellum is involved not only in cognitive but also in motivational processes. |
| doi_str_mv | 10.1016/S0006-8993(98)00847-6 |
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The characteristics of exploration in cerebellectomized +/+ and +/Lc mice suggest that the cerebellum is involved not only in cognitive but also in motivational processes.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(98)00847-6</identifier><identifier>PMID: 9767169</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Anatomical correlates of behavior ; Animals ; Behavior, Animal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; Cerebellum ; Cerebellum - physiology ; Denervation ; Exploration ; Exploratory Behavior - physiology ; Fundamental and applied biological sciences. Psychology ; Habituation ; Habituation, Psychophysiologic - physiology ; Learning - physiology ; Lurcher mutant mouse ; Mice ; Mice, Neurologic Mutants ; Motivation ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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The characteristics of exploration in cerebellectomized +/+ and +/Lc mice suggest that the cerebellum is involved not only in cognitive but also in motivational processes.</description><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cerebellum</subject><subject>Cerebellum - physiology</subject><subject>Denervation</subject><subject>Exploration</subject><subject>Exploratory Behavior - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Habituation</subject><subject>Habituation, Psychophysiologic - physiology</subject><subject>Learning - physiology</subject><subject>Lurcher mutant mouse</subject><subject>Mice</subject><subject>Mice, Neurologic Mutants</subject><subject>Motivation</subject><subject>Psychology. Psychoanalysis. 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Psychophysiology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVIcR23P8GwhxKSw6YjrT5PIYQ2KQQK_TgLWZolCuuVI-2a5t93HRtffRqGeWbe4SFkSeGGApVffwOArLUxzZXR1wCaq1qekTnVitWScTgn8yPykVyU8jK1TWNgRmZGSUWlmZObX6nDKrXV8IyVx4wr7LpxXcW-wn-bLmU3xNRXK3x225jyJ_KhdV3Bz4e6IH-_f_tz_1g__Xz4cX_3VHvOYKg9a5xHz6cIgFZwcAyQIQ-CNjqoEIQWUnnRGCcUV6CYFFL6lkOgIkjVLMjl_u4mp9cRy2DXsfjpNddjGouVxghuqDwJUsmlZlPsgog96HMqJWNrNzmuXX6zFOxOqH0Xane2rNH2XajdBSwPAeNqjeG4dTA4zb8c5q5417XZ9T6WI8Z4Q5XmE3a7x3Cyto2YbfERe48hZvSDDSmeeOQ_4KmPfw</recordid><startdate>19981019</startdate><enddate>19981019</enddate><creator>Caston, J</creator><creator>Chianale, C</creator><creator>Delhaye-Bouchaud, N</creator><creator>Mariani, J</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19981019</creationdate><title>Role of the cerebellum in exploration behavior</title><author>Caston, J ; Chianale, C ; Delhaye-Bouchaud, N ; Mariani, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-c23acec416900f540a20e2e4d5138d7dd58567c539a57470726566cf40d15d673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anatomical correlates of behavior</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cerebellum</topic><topic>Cerebellum - physiology</topic><topic>Denervation</topic><topic>Exploration</topic><topic>Exploratory Behavior - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Habituation</topic><topic>Habituation, Psychophysiologic - physiology</topic><topic>Learning - physiology</topic><topic>Lurcher mutant mouse</topic><topic>Mice</topic><topic>Mice, Neurologic Mutants</topic><topic>Motivation</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caston, J</creatorcontrib><creatorcontrib>Chianale, C</creatorcontrib><creatorcontrib>Delhaye-Bouchaud, N</creatorcontrib><creatorcontrib>Mariani, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caston, J</au><au>Chianale, C</au><au>Delhaye-Bouchaud, N</au><au>Mariani, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the cerebellum in exploration behavior</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1998-10-19</date><risdate>1998</risdate><volume>808</volume><issue>2</issue><spage>232</spage><epage>237</epage><pages>232-237</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Compared to +/+ mice, Lurcher (+/Lc) mutant mice whose cerebellar cortex is lacking almost all Purkinje cells and granule cells, exhibit a low level of exploration; this deficit is not due to a low level of activity but to both a decreased motivation to explore a novel environment and to spatial deficits. 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| ispartof | Brain research, 1998-10, Vol.808 (2), p.232-237 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Anatomical correlates of behavior Animals Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences Cerebellum Cerebellum - physiology Denervation Exploration Exploratory Behavior - physiology Fundamental and applied biological sciences. Psychology Habituation Habituation, Psychophysiologic - physiology Learning - physiology Lurcher mutant mouse Mice Mice, Neurologic Mutants Motivation Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology |
| title | Role of the cerebellum in exploration behavior |
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