Role of the cerebellum in exploration behavior

Compared to +/+ mice, Lurcher (+/Lc) mutant mice whose cerebellar cortex is lacking almost all Purkinje cells and granule cells, exhibit a low level of exploration; this deficit is not due to a low level of activity but to both a decreased motivation to explore a novel environment and to spatial def...

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Veröffentlicht in:	Brain research 1998-10, Vol.808 (2), p.232-237
Hauptverfasser:	Caston, J, Chianale, C, Delhaye-Bouchaud, N, Mariani, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomical correlates of behavior Animals Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences Cerebellum Cerebellum - physiology Denervation Exploration Exploratory Behavior - physiology Fundamental and applied biological sciences. Psychology Habituation Habituation, Psychophysiologic - physiology Learning - physiology Lurcher mutant mouse Mice Mice, Neurologic Mutants Motivation Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology
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Beschreibung
Zusammenfassung:	Compared to +/+ mice, Lurcher (+/Lc) mutant mice whose cerebellar cortex is lacking almost all Purkinje cells and granule cells, exhibit a low level of exploration; this deficit is not due to a low level of activity but to both a decreased motivation to explore a novel environment and to spatial deficits. The characteristics of exploration in cerebellectomized +/+ and +/Lc mice suggest that the cerebellum is involved not only in cognitive but also in motivational processes.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(98)00847-6