Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia
Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 μg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2008-08, Vol.146 (2), p.206-209 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Ragino, Yu. I Vavilin, V. A Salakhutdinov, N. F Makarova, S. I Stakhneva, E. M Safronova, O. G Lyakhovich, V. V Nikitin, Yu. P Tolstikov, G. A |
| description | Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 μg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26-58 and 21-29%, respectively, compared to 200 μg/kg simvastatin, p |
| doi_str_mv | 10.1007/s10517-008-0252-x |
| format | Article |
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I ; Vavilin, V. A ; Salakhutdinov, N. F ; Makarova, S. I ; Stakhneva, E. M ; Safronova, O. G ; Lyakhovich, V. V ; Nikitin, Yu. P ; Tolstikov, G. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>146</volume><issue>2</issue><spage>206</spage><epage>209</epage><pages>206-209</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 μg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26-58 and 21-29%, respectively, compared to 200 μg/kg simvastatin, p<0.05).</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>19145319</pmid><doi>10.1007/s10517-008-0252-x</doi><tpages>4</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Anticholesteremic Agents - therapeutic use antioxidant effect Antioxidants - therapeutic use Aryldialkylphosphatase - blood Biomedical and Life Sciences Biomedicine Biophysics and Biochemistry Cell Biology Cholesterol - blood Diet endothelial dysfunction Endothelin-1 - blood Endothelium, Vascular - drug effects Fluorometry Glycyrrhizic Acid - therapeutic use Hypercholesterolemia - drug therapy Hypercholesterolemia - metabolism hypercholesterolemia in rabbits Internal Medicine Laboratory Medicine Male Nitrous Oxide - metabolism Pathology Rabbits simvaglyzin simvastatin Simvastatin - therapeutic use von Willebrand Factor - metabolism |
| title | Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia |
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