Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia

Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 μg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2008-08, Vol.146 (2), p.206-209
Hauptverfasser:	Ragino, Yu. I, Vavilin, V. A, Salakhutdinov, N. F, Makarova, S. I, Stakhneva, E. M, Safronova, O. G, Lyakhovich, V. V, Nikitin, Yu. P, Tolstikov, G. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anticholesteremic Agents - therapeutic use antioxidant effect Antioxidants - therapeutic use Aryldialkylphosphatase - blood Biomedical and Life Sciences Biomedicine Biophysics and Biochemistry Cell Biology Cholesterol - blood Diet endothelial dysfunction Endothelin-1 - blood Endothelium, Vascular - drug effects Fluorometry Glycyrrhizic Acid - therapeutic use Hypercholesterolemia - drug therapy Hypercholesterolemia - metabolism hypercholesterolemia in rabbits Internal Medicine Laboratory Medicine Male Nitrous Oxide - metabolism Pathology Rabbits simvaglyzin simvastatin Simvastatin - therapeutic use von Willebrand Factor - metabolism
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Zusammenfassung:	Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 μg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26-58 and 21-29%, respectively, compared to 200 μg/kg simvastatin, p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-008-0252-x