Effect of aldosterone on kinetics of intracellular sodium in cortical portion of collecting ducts in rat kidney
We studied the effect of protein kinase C inhibitor RO-31-8220 (10⁻⁷ M) on rapid nongenomic effect of aldosterone in cells of isolated segment of distal region of collecting duct in rat kidney. Experiments with fluorescent dye Na-Green showed that the inhibitor abolished the modulating effect of ald...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2008-08, Vol.146 (2), p.192-195 |
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| creator | Logvinenko, N. S Solenov, E. I Ivanova, L. N |
| description | We studied the effect of protein kinase C inhibitor RO-31-8220 (10⁻⁷ M) on rapid nongenomic effect of aldosterone in cells of isolated segment of distal region of collecting duct in rat kidney. Experiments with fluorescent dye Na-Green showed that the inhibitor abolished the modulating effect of aldosterone (10 nM) on intracellular sodium concentration at external sodium concentration of 14 mM. Aldosterone decreased by half the initial rate of the changes in internal sodium concentration in both 10-day and mature rats (p |
| doi_str_mv | 10.1007/s10517-008-0242-z |
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Similarly to sodium channel blocker amiloride (10⁻⁵ M), RO-31-8220 abolished rapid nongenomic effect of aldosterone on the rate of the changes in internal sodium concentration.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-008-0242-z</identifier><identifier>PMID: 19145315</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>aldosterone ; Aldosterone - administration & dosage ; Aldosterone - metabolism ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Enzyme Inhibitors - pharmacology ; Fluorescence ; General Pathology and Pathophysiology ; In Vitro Techniques ; Indoles - pharmacology ; Internal Medicine ; intracellular sodium ; Intracellular Space - metabolism ; Kidney Tubules, Collecting - drug effects ; Kidney Tubules, Collecting - metabolism ; kidneys ; Laboratory Medicine ; Microdissection ; Pathology ; protein kinase C ; Protein Kinase C - antagonists & inhibitors ; Rats ; Sodium - metabolism</subject><ispartof>Bulletin of experimental biology and medicine, 2008-08, Vol.146 (2), p.192-195</ispartof><rights>Springer Science+Business Media, Inc. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c345t-dff2be6722a2369d05521e4cce068c9821186c859a0b836a2c2af46b76497bd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-008-0242-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-008-0242-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19145315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Logvinenko, N. S</creatorcontrib><creatorcontrib>Solenov, E. I</creatorcontrib><creatorcontrib>Ivanova, L. N</creatorcontrib><title>Effect of aldosterone on kinetics of intracellular sodium in cortical portion of collecting ducts in rat kidney</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the effect of protein kinase C inhibitor RO-31-8220 (10⁻⁷ M) on rapid nongenomic effect of aldosterone in cells of isolated segment of distal region of collecting duct in rat kidney. Experiments with fluorescent dye Na-Green showed that the inhibitor abolished the modulating effect of aldosterone (10 nM) on intracellular sodium concentration at external sodium concentration of 14 mM. Aldosterone decreased by half the initial rate of the changes in internal sodium concentration in both 10-day and mature rats (p<0.05). Similarly to sodium channel blocker amiloride (10⁻⁵ M), RO-31-8220 abolished rapid nongenomic effect of aldosterone on the rate of the changes in internal sodium concentration.</description><subject>aldosterone</subject><subject>Aldosterone - administration & dosage</subject><subject>Aldosterone - metabolism</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fluorescence</subject><subject>General Pathology and Pathophysiology</subject><subject>In Vitro Techniques</subject><subject>Indoles - pharmacology</subject><subject>Internal Medicine</subject><subject>intracellular sodium</subject><subject>Intracellular Space - metabolism</subject><subject>Kidney Tubules, Collecting - drug effects</subject><subject>Kidney Tubules, Collecting - metabolism</subject><subject>kidneys</subject><subject>Laboratory Medicine</subject><subject>Microdissection</subject><subject>Pathology</subject><subject>protein kinase C</subject><subject>Protein Kinase C - antagonists & inhibitors</subject><subject>Rats</subject><subject>Sodium - metabolism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9P3DAQxS1UVLa0H4BLiTj0Fjrjf3GOaAVtJaQeWs6W49ir0Ky92MkBPj2OshISh57G9vzeG9uPkAuEawRovmcEgU0NoGqgnNYvJ2SDomG1ohQ_kA0UqOZKqTPyKefHZQsSP5IzbJELhmJD4q33zk5V9JUZ-5gnl2JwVQzVvyG4abB5aQ1hSsa6cZxHk6oc-2Hel8PKxlQQM1aHZVFEhbVxHIvjEHZVP9spL1wyU_Hrg3v-TE69GbP7cqzn5OHu9u_2Z33_-8ev7c19bRkXU917TzsnG0oNZbLtQQiKjlvrQCrbKoqopFWiNdApJg211Hguu0bytul6YOfk2-p7SPFpdnnS-yEvLzDBxTlr2bYCQfICXr0DH-OcQrmbpsh4i7RhBcIVsinmnJzXhzTsTXrWCHqJQq9R6BKFXqLQL0Xz9Wg8d3vXvymOf18AugK5tMLOpbfJ_3O9XEXeRG12acj64Q8FZFCCXyp7BbGuniI</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Logvinenko, N. 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S ; Solenov, E. I ; Ivanova, L. 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| subjects | aldosterone Aldosterone - administration & dosage Aldosterone - metabolism Animals Biomedical and Life Sciences Biomedicine Cell Biology Enzyme Inhibitors - pharmacology Fluorescence General Pathology and Pathophysiology In Vitro Techniques Indoles - pharmacology Internal Medicine intracellular sodium Intracellular Space - metabolism Kidney Tubules, Collecting - drug effects Kidney Tubules, Collecting - metabolism kidneys Laboratory Medicine Microdissection Pathology protein kinase C Protein Kinase C - antagonists & inhibitors Rats Sodium - metabolism |
| title | Effect of aldosterone on kinetics of intracellular sodium in cortical portion of collecting ducts in rat kidney |
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