Effect of aldosterone on kinetics of intracellular sodium in cortical portion of collecting ducts in rat kidney

We studied the effect of protein kinase C inhibitor RO-31-8220 (10⁻⁷ M) on rapid nongenomic effect of aldosterone in cells of isolated segment of distal region of collecting duct in rat kidney. Experiments with fluorescent dye Na-Green showed that the inhibitor abolished the modulating effect of ald...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2008-08, Vol.146 (2), p.192-195
Hauptverfasser:	Logvinenko, N. S, Solenov, E. I, Ivanova, L. N
Format:	Artikel
Sprache:	eng
Schlagworte:	aldosterone Aldosterone - administration & dosage Aldosterone - metabolism Animals Biomedical and Life Sciences Biomedicine Cell Biology Enzyme Inhibitors - pharmacology Fluorescence General Pathology and Pathophysiology In Vitro Techniques Indoles - pharmacology Internal Medicine intracellular sodium Intracellular Space - metabolism Kidney Tubules, Collecting - drug effects Kidney Tubules, Collecting - metabolism kidneys Laboratory Medicine Microdissection Pathology protein kinase C Protein Kinase C - antagonists & inhibitors Rats Sodium - metabolism
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Zusammenfassung:	We studied the effect of protein kinase C inhibitor RO-31-8220 (10⁻⁷ M) on rapid nongenomic effect of aldosterone in cells of isolated segment of distal region of collecting duct in rat kidney. Experiments with fluorescent dye Na-Green showed that the inhibitor abolished the modulating effect of aldosterone (10 nM) on intracellular sodium concentration at external sodium concentration of 14 mM. Aldosterone decreased by half the initial rate of the changes in internal sodium concentration in both 10-day and mature rats (p
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-008-0242-z