Involvement of the GABA-B system in the mechanism of action of ultralow-dose antibodies to S-100 protein

The involvement of the GABA-B neurotransmitter system in the realization of anxiolytic and antidepressant activities of ultralow-dose antibodies to S-100 protein is demonstrated. Simultaneous injection of ultralow-dose antibodies to S-100 protein and GABA-B receptor agonist baclofen reduced the anxi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2008-05, Vol.145 (5), p.614-616
Hauptverfasser:	Kheifez, I. A., Molodavkin, G. M., Voronina, T. A., Dugina, Yu. L., Sergeeva, S. A., Epstein, O. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Antibodies Antibodies - administration & dosage Antidepressants Antidepressive Agents - pharmacology Anxiety - drug therapy Anxiety - etiology Anxiety - immunology Anxiolytics Baclofen Baclofen - pharmacology Benzodiazepines Biomedical and Life Sciences Biomedicine Cell Biology Depression - drug therapy Depression - etiology Depression - immunology Diazepam Diazepam - pharmacology Dose-Response Relationship, Immunologic GABA Agonists - pharmacology GABA Antagonists - pharmacology Internal Medicine Laboratory Medicine Male Pathology Proteins Rats Receptors, GABA-B - immunology S100 protein S100 Proteins - antagonists & inhibitors S100 Proteins - immunology Tricyclic antidepressants γ-Aminobutyric acid γ-Aminobutyric acid B receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The involvement of the GABA-B neurotransmitter system in the realization of anxiolytic and antidepressant activities of ultralow-dose antibodies to S-100 protein is demonstrated. Simultaneous injection of ultralow-dose antibodies to S-100 protein and GABA-B receptor agonist baclofen reduced the anxiolytic and antidepressant effects of the drug, while GABA-B receptor antagonist faclofen stimulated the anxiolytic and reduced the antidepressant effect of ultralow-dose antibodies to S-100 protein. The effect of ultralow-dose antibodies to S-100 protein on the GABA-B-ergic system differs from that of benzodiazepine anxiolytics (diazepam) and tricyclic antidepressants (amitryptiline) not affecting this transmitter system.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-008-0154-y