Protein C and S Deficiency

Abstract Protein C and S deficiency states predispose affected individuals to thrombosis, especially venous thrombosis of the lower extremities, usually beginning in the teenage years. Treatment of these patients is generally with oral anticoagulation, following initial heparinization. The classific...

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Veröffentlicht in:	Seminars in thrombosis and hemostasis 1999-01, Vol.25 (3), p.265-272
Hauptverfasser:	Nizzi, Frank A., Kaplan, Harold S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Protein C Deficiency - blood Protein C Deficiency - classification Protein C Deficiency - genetics Protein S Deficiency - blood Protein S Deficiency - classification Protein S Deficiency - genetics
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Beschreibung
Zusammenfassung:	Abstract Protein C and S deficiency states predispose affected individuals to thrombosis, especially venous thrombosis of the lower extremities, usually beginning in the teenage years. Treatment of these patients is generally with oral anticoagulation, following initial heparinization. The classification of the deficiency states is dependent upon determination of the quantity and functional activity of either protein.
ISSN:	0094-6176 1098-9064
DOI:	10.1055/s-2007-994930