Syntheses of trans-5- Oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-Oxo-hexahydro-furo[3,2-b]pyrroles (Pyrrolidine trans-Lactams and trans-Lactones): New Pharmacophores for Elastase Inhibition

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Veröffentlicht in:	Journal of medicinal chemistry 1998-10, Vol.41 (21), p.3919-3922
Hauptverfasser:	Macdonald, Simon J. F, Belton, David J, Buckley, Doreen M, Spooner, Julie E, Anson, Michael S, Harrison, Lee A, Mills, Keith, Upton, Richard J, Dowle, Michael D, Smith, Robin A, Molloy, Christopher R, Risley, Catherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Azetidines - pharmacology Biological and medical sciences Humans Lactams - chemical synthesis Lactams - pharmacology Lactones - chemical synthesis Lactones - pharmacology Leukocyte Elastase - antagonists & inhibitors Medical sciences Neutrophils - enzymology Pharmacology. Drug treatments Piperazines - pharmacology Respiratory system Serine Proteinase Inhibitors - chemical synthesis Serine Proteinase Inhibitors - pharmacology Structure-Activity Relationship
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