Association of Specific Subtypes of Borrelia burgdorferi with Hematogenous Dissemination in Early Lyme Disease
To investigate whether genetic diversity of Borrelia burgdorferi sensu stricto may affect the occurrence of hematogenous dissemination, 104 untreated adults with erythema migrans from a Lyme disease diagnostic center in Westchester County, New York, were studied. Cultured skin isolates were classifi...
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| Veröffentlicht in: | The Journal of infectious diseases 1999-09, Vol.180 (3), p.720-725 |
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| container_title | The Journal of infectious diseases |
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| creator | Wormser, Gary P. Liveris, Dionysios Nowakowski, John Nadelman, Robert B. Cavaliere, L. Frank McKenna, Donna Holmgren, Diane Schwartz, Ira |
| description | To investigate whether genetic diversity of Borrelia burgdorferi sensu stricto may affect the occurrence of hematogenous dissemination, 104 untreated adults with erythema migrans from a Lyme disease diagnostic center in Westchester County, New York, were studied. Cultured skin isolates were classified into 3 groups by a polymerase chain reaction amplification and restriction fragment length polymorphism (RFLP) method. A highly significant association between infecting RFLP type in skin and the presence of spirochetemia was found (P |
| doi_str_mv | 10.1086/314922 |
| format | Article |
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Frank ; McKenna, Donna ; Holmgren, Diane ; Schwartz, Ira</creator><creatorcontrib>Wormser, Gary P. ; Liveris, Dionysios ; Nowakowski, John ; Nadelman, Robert B. ; Cavaliere, L. Frank ; McKenna, Donna ; Holmgren, Diane ; Schwartz, Ira</creatorcontrib><description>To investigate whether genetic diversity of Borrelia burgdorferi sensu stricto may affect the occurrence of hematogenous dissemination, 104 untreated adults with erythema migrans from a Lyme disease diagnostic center in Westchester County, New York, were studied. Cultured skin isolates were classified into 3 groups by a polymerase chain reaction amplification and restriction fragment length polymorphism (RFLP) method. A highly significant association between infecting RFLP type in skin and the presence of spirochetemia was found (P <.001). The same association existed for the presence of multiple erythema migrans lesions (P = .045), providing clinical corroboration that hematogenous dissemination is related to the genetic subtype of B. burgdorferi sensu stricto. There were no significant associations between RFLP type and seropositivity or clinical symptoms and signs except for a history of fever and chills (P = .033). These results suggest that specific genetic subtypes of B. burgdorferi sensu stricto influence disease pathogenesis. Infection with different subtypes of B. burgdorferi sensu stricto may help to explain differences in the clinical presentation of patients with Lyme disease.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/314922</identifier><identifier>PMID: 10438360</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Bacterial diseases ; Bacteriology ; Biological and medical sciences ; Biopsy ; Blood ; Borrelia ; Borrelia burgdorferi ; Borrelia burgdorferi Group - classification ; Borrelia burgdorferi Group - genetics ; Borrelia burgdorferi Group - isolation & purification ; Borrelia infections ; Epidemiology ; Erythema ; Erythema Chronicum Migrans - microbiology ; Erythema Chronicum Migrans - pathology ; Erythema Chronicum Migrans - physiopathology ; Fundamental and applied biological sciences. Psychology ; Genetic Variation ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Lesions ; Lyme disease ; Lyme Disease - microbiology ; Lyme Disease - pathology ; Lyme Disease - physiopathology ; Major Articles ; Medical sciences ; Microbiology ; Phylogeny ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Skin ; Skin - microbiology ; Skin - pathology ; Symptoms ; Tropical bacterial diseases</subject><ispartof>The Journal of infectious diseases, 1999-09, Vol.180 (3), p.720-725</ispartof><rights>Copyright 1999 Infectious Diseases Society of America</rights><rights>1999 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Sep 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-d19a3622dc6393a176fd043a6b4d9078f157ec01761e64e50338d98d9544a9443</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30111080$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30111080$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1916542$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10438360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wormser, Gary P.</creatorcontrib><creatorcontrib>Liveris, Dionysios</creatorcontrib><creatorcontrib>Nowakowski, John</creatorcontrib><creatorcontrib>Nadelman, Robert B.</creatorcontrib><creatorcontrib>Cavaliere, L. Frank</creatorcontrib><creatorcontrib>McKenna, Donna</creatorcontrib><creatorcontrib>Holmgren, Diane</creatorcontrib><creatorcontrib>Schwartz, Ira</creatorcontrib><title>Association of Specific Subtypes of Borrelia burgdorferi with Hematogenous Dissemination in Early Lyme Disease</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>To investigate whether genetic diversity of Borrelia burgdorferi sensu stricto may affect the occurrence of hematogenous dissemination, 104 untreated adults with erythema migrans from a Lyme disease diagnostic center in Westchester County, New York, were studied. Cultured skin isolates were classified into 3 groups by a polymerase chain reaction amplification and restriction fragment length polymorphism (RFLP) method. A highly significant association between infecting RFLP type in skin and the presence of spirochetemia was found (P <.001). The same association existed for the presence of multiple erythema migrans lesions (P = .045), providing clinical corroboration that hematogenous dissemination is related to the genetic subtype of B. burgdorferi sensu stricto. There were no significant associations between RFLP type and seropositivity or clinical symptoms and signs except for a history of fever and chills (P = .033). These results suggest that specific genetic subtypes of B. burgdorferi sensu stricto influence disease pathogenesis. Infection with different subtypes of B. burgdorferi sensu stricto may help to explain differences in the clinical presentation of patients with Lyme disease.</description><subject>Adult</subject><subject>Bacterial diseases</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blood</subject><subject>Borrelia</subject><subject>Borrelia burgdorferi</subject><subject>Borrelia burgdorferi Group - classification</subject><subject>Borrelia burgdorferi Group - genetics</subject><subject>Borrelia burgdorferi Group - isolation & purification</subject><subject>Borrelia infections</subject><subject>Epidemiology</subject><subject>Erythema</subject><subject>Erythema Chronicum Migrans - microbiology</subject><subject>Erythema Chronicum Migrans - pathology</subject><subject>Erythema Chronicum Migrans - physiopathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lesions</subject><subject>Lyme disease</subject><subject>Lyme Disease - microbiology</subject><subject>Lyme Disease - pathology</subject><subject>Lyme Disease - physiopathology</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Phylogeny</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Skin</subject><subject>Skin - microbiology</subject><subject>Skin - pathology</subject><subject>Symptoms</subject><subject>Tropical bacterial diseases</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhoModtvqP1CCSO9G8zXJ5LKutSusCG0F8SZkM2dq1pnJNpmh7r83wyyteCMEEs778JwTDkIvKXlHSSXfcyo0Y0_QgpZcFVJS_hQtCGGsoJXWR-g4pS0hRHCpnqMjmh8Vl2SB-vOUgvN28KHHocHXO3C-8Q5fj5thv4M0FT-EGKH1Fm_GeFuH2ED0-N4PP_EKOjuEW-jDmPBHnxJ0vp9lvscXNrZ7vN53MGVgE5yiZ41tE7w43Cfo26eLm-WqWH-9_Lw8XxdOMDYUNdWWS8ZqJ7nmlirZ1HlkKzei1kRVDS0VOJLrFKSAknBe1TqfUgirheAn6Gz27mK4GyENpvPJQdvaHvKoRmotlFDqvyCtSEW0rjL45h9wG8bY508YxrgmQkv5aHMxpBShMbvoOxv3hhIz7cnMe8rg64Nt3HRQ_4XNi8nA2wNgk7NtE23vfHrkNJWlmDyvZmybhhAfYk4oze0mTTHnPg3w-yG38ZeRiqvSrL7_MOTL1Y1crqSR_A_r1LCK</recordid><startdate>19990901</startdate><enddate>19990901</enddate><creator>Wormser, Gary P.</creator><creator>Liveris, Dionysios</creator><creator>Nowakowski, John</creator><creator>Nadelman, Robert B.</creator><creator>Cavaliere, L. Frank</creator><creator>McKenna, Donna</creator><creator>Holmgren, Diane</creator><creator>Schwartz, Ira</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19990901</creationdate><title>Association of Specific Subtypes of Borrelia burgdorferi with Hematogenous Dissemination in Early Lyme Disease</title><author>Wormser, Gary P. ; Liveris, Dionysios ; Nowakowski, John ; Nadelman, Robert B. ; Cavaliere, L. 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Psychology</topic><topic>Genetic Variation</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lesions</topic><topic>Lyme disease</topic><topic>Lyme Disease - microbiology</topic><topic>Lyme Disease - pathology</topic><topic>Lyme Disease - physiopathology</topic><topic>Major Articles</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Phylogeny</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Skin</topic><topic>Skin - microbiology</topic><topic>Skin - pathology</topic><topic>Symptoms</topic><topic>Tropical bacterial diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wormser, Gary P.</creatorcontrib><creatorcontrib>Liveris, Dionysios</creatorcontrib><creatorcontrib>Nowakowski, John</creatorcontrib><creatorcontrib>Nadelman, Robert B.</creatorcontrib><creatorcontrib>Cavaliere, L. Frank</creatorcontrib><creatorcontrib>McKenna, Donna</creatorcontrib><creatorcontrib>Holmgren, Diane</creatorcontrib><creatorcontrib>Schwartz, Ira</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wormser, Gary P.</au><au>Liveris, Dionysios</au><au>Nowakowski, John</au><au>Nadelman, Robert B.</au><au>Cavaliere, L. Frank</au><au>McKenna, Donna</au><au>Holmgren, Diane</au><au>Schwartz, Ira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Specific Subtypes of Borrelia burgdorferi with Hematogenous Dissemination in Early Lyme Disease</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>180</volume><issue>3</issue><spage>720</spage><epage>725</epage><pages>720-725</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To investigate whether genetic diversity of Borrelia burgdorferi sensu stricto may affect the occurrence of hematogenous dissemination, 104 untreated adults with erythema migrans from a Lyme disease diagnostic center in Westchester County, New York, were studied. Cultured skin isolates were classified into 3 groups by a polymerase chain reaction amplification and restriction fragment length polymorphism (RFLP) method. A highly significant association between infecting RFLP type in skin and the presence of spirochetemia was found (P <.001). The same association existed for the presence of multiple erythema migrans lesions (P = .045), providing clinical corroboration that hematogenous dissemination is related to the genetic subtype of B. burgdorferi sensu stricto. There were no significant associations between RFLP type and seropositivity or clinical symptoms and signs except for a history of fever and chills (P = .033). These results suggest that specific genetic subtypes of B. burgdorferi sensu stricto influence disease pathogenesis. Infection with different subtypes of B. burgdorferi sensu stricto may help to explain differences in the clinical presentation of patients with Lyme disease.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10438360</pmid><doi>10.1086/314922</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of infectious diseases, 1999-09, Vol.180 (3), p.720-725 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Bacterial diseases Bacteriology Biological and medical sciences Biopsy Blood Borrelia Borrelia burgdorferi Borrelia burgdorferi Group - classification Borrelia burgdorferi Group - genetics Borrelia burgdorferi Group - isolation & purification Borrelia infections Epidemiology Erythema Erythema Chronicum Migrans - microbiology Erythema Chronicum Migrans - pathology Erythema Chronicum Migrans - physiopathology Fundamental and applied biological sciences. Psychology Genetic Variation Human bacterial diseases Humans Infections Infectious diseases Lesions Lyme disease Lyme Disease - microbiology Lyme Disease - pathology Lyme Disease - physiopathology Major Articles Medical sciences Microbiology Phylogeny Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Skin Skin - microbiology Skin - pathology Symptoms Tropical bacterial diseases |
| title | Association of Specific Subtypes of Borrelia burgdorferi with Hematogenous Dissemination in Early Lyme Disease |
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