Association of Specific Subtypes of Borrelia burgdorferi with Hematogenous Dissemination in Early Lyme Disease

To investigate whether genetic diversity of Borrelia burgdorferi sensu stricto may affect the occurrence of hematogenous dissemination, 104 untreated adults with erythema migrans from a Lyme disease diagnostic center in Westchester County, New York, were studied. Cultured skin isolates were classifi...

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Veröffentlicht in:	The Journal of infectious diseases 1999-09, Vol.180 (3), p.720-725
Hauptverfasser:	Wormser, Gary P., Liveris, Dionysios, Nowakowski, John, Nadelman, Robert B., Cavaliere, L. Frank, McKenna, Donna, Holmgren, Diane, Schwartz, Ira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bacterial diseases Bacteriology Biological and medical sciences Biopsy Blood Borrelia Borrelia burgdorferi Borrelia burgdorferi Group - classification Borrelia burgdorferi Group - genetics Borrelia burgdorferi Group - isolation & purification Borrelia infections Epidemiology Erythema Erythema Chronicum Migrans - microbiology Erythema Chronicum Migrans - pathology Erythema Chronicum Migrans - physiopathology Fundamental and applied biological sciences. Psychology Genetic Variation Human bacterial diseases Humans Infections Infectious diseases Lesions Lyme disease Lyme Disease - microbiology Lyme Disease - pathology Lyme Disease - physiopathology Major Articles Medical sciences Microbiology Phylogeny Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Skin Skin - microbiology Skin - pathology Symptoms Tropical bacterial diseases
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Zusammenfassung:	To investigate whether genetic diversity of Borrelia burgdorferi sensu stricto may affect the occurrence of hematogenous dissemination, 104 untreated adults with erythema migrans from a Lyme disease diagnostic center in Westchester County, New York, were studied. Cultured skin isolates were classified into 3 groups by a polymerase chain reaction amplification and restriction fragment length polymorphism (RFLP) method. A highly significant association between infecting RFLP type in skin and the presence of spirochetemia was found (P
ISSN:	0022-1899 1537-6613
DOI:	10.1086/314922