Hydroxylamine blocks pre- but not postsynaptic adenosine A(1) receptor-mediated actions in rat hippocampus

The commonly used nitric oxide donor, hydroxylamine (NH(2)OH), can block or reverse the inhibition of glutamatergic transmission by adenosine or an adenosine A(1) agonist in rat hippocampal slice. In these experiments, hydroxylamine did not affect the adenosine A(1) receptor-mediated depression of p...

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Veröffentlicht in:	Brain research 1999-08, Vol.837 (1-2), p.309-313
Hauptverfasser:	Fowler, J C, Gervitz, L, Partridge, L D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Animals Calcium - pharmacology Evoked Potentials - drug effects Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Hippocampus - drug effects Hippocampus - physiology Hydroxylamine - pharmacology In Vitro Techniques Magnesium - pharmacology Male Nitric Oxide Donors - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Purinergic P1 Receptor Antagonists Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Receptors, Purinergic P1 - physiology Synapses - drug effects Synapses - physiology
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Zusammenfassung:	The commonly used nitric oxide donor, hydroxylamine (NH(2)OH), can block or reverse the inhibition of glutamatergic transmission by adenosine or an adenosine A(1) agonist in rat hippocampal slice. In these experiments, hydroxylamine did not affect the adenosine A(1) receptor-mediated depression of postsynaptic excitability. We conclude that hydroxylamine acts presynaptically to counter adenosine A(1) receptor-mediated inhibition of synaptic transmission.
ISSN:	0006-8993
DOI:	10.1016/S0006-8993(99)01659-5