The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology Today 1999-08, Vol.20 (8), p.375-382
Hauptverfasser:	Lupher, Mark L, Rao, Navin, Eck, Michael J, Band, Hamid
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Leukocytes - immunology Leukocytes - metabolism Lymphocyte Models, Biological Models, Molecular Protein Conformation Protein tyrosine kinase Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - immunology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-cbl Protooncogene Receptor Receptors, Immunologic - metabolism Signal transduction Signal Transduction - immunology SYK/ZAP-70 Ubiquitin-Protein Ligases
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Beschreibung
Zusammenfassung:	The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.
ISSN:	0167-5699
DOI:	10.1016/S0167-5699(99)01484-X