Transfer RNAs and pathogenicity islands

Transfer RNAs and pathogenicity islands

The tRNAs are central components in translation. In addition, they are essential for replication of retroviruses: tRNAs bind to viral genomes through their 3′-end sequences and act as primers for initiation of viral replication. Here, I discuss the possibility that tRNAs also play a role in the hori...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 1999-08, Vol.24 (8), p.295-298
1. Verfasser: Hou, Ya-Ming
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria - genetics
Bacteria - pathogenicity
Base Sequence
Excision
Gene Transfer, Horizontal
Hybrid
Integration
Models, Biological
Pathogenicity island
Recombination
Recombination, Genetic
RNA, Bacterial - genetics
RNA, Transfer - genetics
Transfer RNA (tRNA)
Virulence - genetics
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Zusammenfassung:The tRNAs are central components in translation. In addition, they are essential for replication of retroviruses: tRNAs bind to viral genomes through their 3′-end sequences and act as primers for initiation of viral replication. Here, I discuss the possibility that tRNAs also play a role in the horizontal transfer of bacterial pathogenicity islands between different pathogens. Such a role would implicate tRNAs in DNA recombination.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(99)01428-0