Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation

Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation

Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it was found that introduction of a sulfonamide also influenced the stability of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioorganic & medicinal chemistry 1999-06, Vol.7 (6), p.1043-1047
Hauptverfasser: de Bont, Dries B.A., Sliedregt-Bol, Karen M., Hofmeyer, Lovina J.F., Liskamp, Rob M.J.
Format: Artikel
Sprache:eng
Schlagworte:
aminoacids and derivatives
Binding Sites
Catalysis
Chemistry
Endopeptidases - metabolism
Exact sciences and technology
isosteres
Organic chemistry
Peptides
Peptides - chemistry
Peptides - metabolism
Peptides and polypeptides
Preparations and properties
solid-phase synthesis
Substrate Specificity
Sulfonamides - chemistry
Sulfonamides - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it was found that introduction of a sulfonamide also influenced the stability of adjacent amide bonds.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(99)00021-8