Airway patterning: A paradigm for restricted signalling

Intercellular signalling is limited by the range of cell responsiveness, often mediated by repressors. A recently identified repressor, Sprouty, inhibits MAP kinase signalling in flies, mice and humans and has a conserved function in patterning the airways of these divergent species.

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Bibliographische Detailangaben
Veröffentlicht in:	Current biology 1999-07, Vol.9 (14), p.R506-R510
Hauptverfasser:	Placzek, Marysia, Skaer, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Developmental Biology Drosophila Drosophila Proteins Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Genetics Insect Proteins - physiology Lung - embryology MAP Kinase Signaling System Membrane Proteins Mice Mice, Knockout Models, Biological Signal Transduction Trachea - metabolism Trachea - physiology
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Beschreibung
Zusammenfassung:	Intercellular signalling is limited by the range of cell responsiveness, often mediated by repressors. A recently identified repressor, Sprouty, inhibits MAP kinase signalling in flies, mice and humans and has a conserved function in patterning the airways of these divergent species.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/S0960-9822(99)80322-4