Inhibition of cathepsin D by tripeptides containing statine analogs

Various analogs of statine, a remarkable amino acid component of the protease inhibitor pepstatine, were synthesized and evaluated as tripeptide derivatives for their activity against cathepsin D and HIV-1 protease.

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Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 1999-07, Vol.58 (2), p.329-333
Hauptverfasser:	Bessodes, Michel, Antonakis, Kostas, Herscovici, Jean, Garcia, Marcel, Rochefort, Henri, Capony, Françoise, Lelièvre, Yves, Scherman, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acids - chemistry Amino Acids - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic agents Antiviral agents Biological and medical sciences cathepsin D Cathepsin D - antagonists & inhibitors cell proliferation General aspects HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology Humans inhibitor Medical sciences Oligopeptides - chemistry Oligopeptides - pharmacology Pepstatins - chemistry Pharmacology. Drug treatments protease Protease Inhibitors - chemistry Protease Inhibitors - pharmacology statine Structure-Activity Relationship tripeptide Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Various analogs of statine, a remarkable amino acid component of the protease inhibitor pepstatine, were synthesized and evaluated as tripeptide derivatives for their activity against cathepsin D and HIV-1 protease.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/S0006-2952(99)00103-3