Impact of experimental peritonitis on bone marrow cell function

Background: The effects of abdominal sepsis on the regulation of cell turnover in bone marrow and on the function of hematopoietic stem cells were investigated. Methods: In a new mouse model of abdominal sepsis (colon ascendens stent peritonitis [CASP]) the proliferation, apoptosis, and colony-formi...

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Veröffentlicht in:	Surgery 1999-07, Vol.126 (1), p.41-47
Hauptverfasser:	Barthlen, Winfried, Zantl, Nikolaus, Pfeffer, Klaus, Heidecke, Claus-Dieter, Holzmann, Bernhard, Stadler, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Animals Apoptosis Biological and medical sciences Bone Marrow Cells - physiology Cell Division Cytokines - pharmacology Female Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Hematopoietic Stem Cells - physiology Lipopolysaccharides - pharmacology Medical sciences Mice Mice, Inbred C57BL Peritonitis - pathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system
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Zusammenfassung:	Background: The effects of abdominal sepsis on the regulation of cell turnover in bone marrow and on the function of hematopoietic stem cells were investigated. Methods: In a new mouse model of abdominal sepsis (colon ascendens stent peritonitis [CASP]) the proliferation, apoptosis, and colony-forming capacity of bone marrow cells were determined. Results: Both experimental peritonitis and sham surgery increased proliferation of bone marrow cells significantly (P
ISSN:	0039-6060 1532-7361
DOI:	10.1067/msy.1999.99060