Randomised trial of intradermal Mycobacterium vaccae or intradermal hepatitis B immunisation in children with HIV infection
This study assessed the safety of inactivated Mycobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection. 35 children ages 1–8 with CD4 counts ≥300/mm 3 in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3...
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| Veröffentlicht in: | Vaccine 1999-06, Vol.17 (20), p.2583-2587 |
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| container_issue | 20 |
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| container_title | Vaccine |
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| creator | Johnson, Daniel Waddell, Richard D. Pelton, Steven I. Jaeger, Anna S. Modlin, John F. Yogev, Ram Morin, Paul Arbeit, Robert D. Fordham von Reyn, C. |
| description | This study assessed the safety of inactivated
Mycobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection. 35 children ages 1–8 with CD4 counts ≥300/mm
3 in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3-dose series of intradermal
M. vaccae vaccine (MV) or hepatitis B vaccine (HBV) at 2-month intervals. Immunisation was safe and well tolerated; 2-day median vaccine site induration was 5 mm in MV recipients and 0 mm in HBV recipients (
p |
| doi_str_mv | 10.1016/S0264-410X(99)00055-9 |
| format | Article |
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Mycobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection. 35 children ages 1–8 with CD4 counts ≥300/mm
3 in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3-dose series of intradermal
M. vaccae vaccine (MV) or hepatitis B vaccine (HBV) at 2-month intervals. Immunisation was safe and well tolerated; 2-day median vaccine site induration was 5 mm in MV recipients and 0 mm in HBV recipients (
p<0.001). There were no significantly different changes in viral load or CD4 count between the two vaccine groups. No PPD skin test conversions occurred after immunisation. MV is safe and well tolerated and deserves further evaluation as a vaccine to prevent mycobacterial disease in HIV-infected children.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(99)00055-9</identifier><identifier>PMID: 10418906</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Cutaneous ; Adolescent ; AIDS/HIV ; Antibodies, Bacterial - blood ; Bacterial Vaccines - immunology ; Biological and medical sciences ; CD4 Lymphocyte Count ; Child ; Child, Preschool ; Double-Blind Method ; Epidemiology. Vaccinations ; General aspects ; Hepatitis B Antibodies - blood ; Hepatitis B Vaccines - immunology ; HIV ; HIV Infections - immunology ; Humans ; Immunisation ; Immunization ; Infant ; Infectious diseases ; Lymphocyte Activation ; Medical sciences ; Mycobacteria ; Mycobacterium - immunology ; Skin Tests</subject><ispartof>Vaccine, 1999-06, Vol.17 (20), p.2583-2587</ispartof><rights>1999 Elsevier Science Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0264-410X(99)00055-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1874772$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10418906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Daniel</creatorcontrib><creatorcontrib>Waddell, Richard D.</creatorcontrib><creatorcontrib>Pelton, Steven I.</creatorcontrib><creatorcontrib>Jaeger, Anna S.</creatorcontrib><creatorcontrib>Modlin, John F.</creatorcontrib><creatorcontrib>Yogev, Ram</creatorcontrib><creatorcontrib>Morin, Paul</creatorcontrib><creatorcontrib>Arbeit, Robert D.</creatorcontrib><creatorcontrib>Fordham von Reyn, C.</creatorcontrib><title>Randomised trial of intradermal Mycobacterium vaccae or intradermal hepatitis B immunisation in children with HIV infection</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>This study assessed the safety of inactivated
Mycobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection. 35 children ages 1–8 with CD4 counts ≥300/mm
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M. vaccae vaccine (MV) or hepatitis B vaccine (HBV) at 2-month intervals. Immunisation was safe and well tolerated; 2-day median vaccine site induration was 5 mm in MV recipients and 0 mm in HBV recipients (
p<0.001). There were no significantly different changes in viral load or CD4 count between the two vaccine groups. No PPD skin test conversions occurred after immunisation. MV is safe and well tolerated and deserves further evaluation as a vaccine to prevent mycobacterial disease in HIV-infected children.</description><subject>Administration, Cutaneous</subject><subject>Adolescent</subject><subject>AIDS/HIV</subject><subject>Antibodies, Bacterial - blood</subject><subject>Bacterial Vaccines - immunology</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Double-Blind Method</subject><subject>Epidemiology. Vaccinations</subject><subject>General aspects</subject><subject>Hepatitis B Antibodies - blood</subject><subject>Hepatitis B Vaccines - immunology</subject><subject>HIV</subject><subject>HIV Infections - immunology</subject><subject>Humans</subject><subject>Immunisation</subject><subject>Immunization</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Lymphocyte Activation</subject><subject>Medical sciences</subject><subject>Mycobacteria</subject><subject>Mycobacterium - immunology</subject><subject>Skin Tests</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0V1rFTEQBuBQKva0-hOUXBSpF6vJJrubXIkWtYWK0C-8C3Mms5zIfhyT3Urxz5ttj4pXYZKHgTcvYy-keCOFrN9eibLWhZbi24m1r4UQVVXYPbaSplFFWUmzz1Z_yQE7TOn7gpS0T9mBFFoaK-oV-3UJgx_7kMjzKQbo-NjyMEwRPMU-j1_ucVwDThTD3PM7QATiY_zPbGgLU5hC4h946Pt5CCnP45ARx03ofKSB_wzThp-d3-bLlnB5fsaetNAler47j9jNp4_Xp2fFxdfP56fvLwoqbTkVZHUpVY0eWiWkAtRWYdNAVecQlUIstbeK1sbUUtLaKg0GZCOpNAaVqNURe_W4dxvHHzOlyeW8SF0HA41zcrW1UupqgS93cF735N02hh7ivfvzXRkc7wAkhK6NMGBI_5xpdNOUmb17ZJRT3QWKLmGgAcmHmKM7P4a80y09uoce3VKSs9Y99Ois-g1-14_Y</recordid><startdate>19990604</startdate><enddate>19990604</enddate><creator>Johnson, Daniel</creator><creator>Waddell, Richard D.</creator><creator>Pelton, Steven I.</creator><creator>Jaeger, Anna S.</creator><creator>Modlin, John F.</creator><creator>Yogev, Ram</creator><creator>Morin, Paul</creator><creator>Arbeit, Robert D.</creator><creator>Fordham von Reyn, C.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19990604</creationdate><title>Randomised trial of intradermal Mycobacterium vaccae or intradermal hepatitis B immunisation in children with HIV infection</title><author>Johnson, Daniel ; Waddell, Richard D. ; Pelton, Steven I. ; Jaeger, Anna S. ; Modlin, John F. ; Yogev, Ram ; Morin, Paul ; Arbeit, Robert D. ; Fordham von Reyn, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e292t-e942136cdaf3013ac493c77a5641853cc24d93eb88611eb934a8a171e288c3063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Cutaneous</topic><topic>Adolescent</topic><topic>AIDS/HIV</topic><topic>Antibodies, Bacterial - blood</topic><topic>Bacterial Vaccines - immunology</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Double-Blind Method</topic><topic>Epidemiology. 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3 in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3-dose series of intradermal
M. vaccae vaccine (MV) or hepatitis B vaccine (HBV) at 2-month intervals. Immunisation was safe and well tolerated; 2-day median vaccine site induration was 5 mm in MV recipients and 0 mm in HBV recipients (
p<0.001). There were no significantly different changes in viral load or CD4 count between the two vaccine groups. No PPD skin test conversions occurred after immunisation. MV is safe and well tolerated and deserves further evaluation as a vaccine to prevent mycobacterial disease in HIV-infected children.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10418906</pmid><doi>10.1016/S0264-410X(99)00055-9</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
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| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Cutaneous Adolescent AIDS/HIV Antibodies, Bacterial - blood Bacterial Vaccines - immunology Biological and medical sciences CD4 Lymphocyte Count Child Child, Preschool Double-Blind Method Epidemiology. Vaccinations General aspects Hepatitis B Antibodies - blood Hepatitis B Vaccines - immunology HIV HIV Infections - immunology Humans Immunisation Immunization Infant Infectious diseases Lymphocyte Activation Medical sciences Mycobacteria Mycobacterium - immunology Skin Tests |
| title | Randomised trial of intradermal Mycobacterium vaccae or intradermal hepatitis B immunisation in children with HIV infection |
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