Randomised trial of intradermal Mycobacterium vaccae or intradermal hepatitis B immunisation in children with HIV infection

This study assessed the safety of inactivated Mycobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection. 35 children ages 1–8 with CD4 counts ≥300/mm 3 in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 1999-06, Vol.17 (20), p.2583-2587
Hauptverfasser:	Johnson, Daniel, Waddell, Richard D., Pelton, Steven I., Jaeger, Anna S., Modlin, John F., Yogev, Ram, Morin, Paul, Arbeit, Robert D., Fordham von Reyn, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Adolescent AIDS/HIV Antibodies, Bacterial - blood Bacterial Vaccines - immunology Biological and medical sciences CD4 Lymphocyte Count Child Child, Preschool Double-Blind Method Epidemiology. Vaccinations General aspects Hepatitis B Antibodies - blood Hepatitis B Vaccines - immunology HIV HIV Infections - immunology Humans Immunisation Immunization Infant Infectious diseases Lymphocyte Activation Medical sciences Mycobacteria Mycobacterium - immunology Skin Tests
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	This study assessed the safety of inactivated Mycobacterium vaccae as a candidate vaccine to prevent disseminated mycobacterial disease in children with HIV infection. 35 children ages 1–8 with CD4 counts ≥300/mm 3 in New Hampshire, Boston and Chicago were randomised in a 2:1 schedule to receive a 3-dose series of intradermal M. vaccae vaccine (MV) or hepatitis B vaccine (HBV) at 2-month intervals. Immunisation was safe and well tolerated; 2-day median vaccine site induration was 5 mm in MV recipients and 0 mm in HBV recipients ( p
ISSN:	0264-410X 1873-2518
DOI:	10.1016/S0264-410X(99)00055-9