Prophylactic oral amiodarone compared with placebo for prevention of atrial fibrillation after coronary artery bypass surgery

Prophylactic oral amiodarone compared with placebo for prevention of atrial fibrillation after coronary artery bypass surgery

Background Postoperative atrial fibrillation occurs in 20% to 40% of patients undergoing coronary artery bypass grafting (CABG) and contributes to delayed recovery, increased length of stay, and increased hospital cost. Measures at preventing postoperative atrial fibrillation have had mixed results....

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Veröffentlicht in:The American heart journal 1999-07, Vol.138 (1), p.144-150
Hauptverfasser: Redle, Joseph D., Khurana, Sandeep, Marzan, Rey, McCullough, Peter A., Stewart, James R., Westveer, Douglas C., O'Neill, William W., Bassett, Joseph S., Tepe, Nicholas A., Frumin, Howard I.
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adrenergic beta-Antagonists - therapeutic use
Aged
Amiodarone - administration & dosage
Amiodarone - therapeutic use
Anti-Arrhythmia Agents - administration & dosage
Anti-Arrhythmia Agents - therapeutic use
Antiarythmic agents
Atrial Fibrillation - etiology
Atrial Fibrillation - physiopathology
Atrial Fibrillation - prevention & control
Biological and medical sciences
Cardiovascular system
Coronary Artery Bypass - adverse effects
Double-Blind Method
Drug Therapy, Combination
Female
Heart Rate - drug effects
Humans
Incidence
Length of Stay
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Time Factors
Treatment Outcome
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Zusammenfassung:Background Postoperative atrial fibrillation occurs in 20% to 40% of patients undergoing coronary artery bypass grafting (CABG) and contributes to delayed recovery, increased length of stay, and increased hospital cost. Measures at preventing postoperative atrial fibrillation have had mixed results. We report a double-blind trial comparing oral amiodarone with placebo for the prevention of atrial fibrillation after CABG. Methods And Results All patients undergoing CABG were considered eligible. Exclusion criteria included bradycardia (
ISSN:0002-8703
1097-6744
DOI:10.1016/S0002-8703(99)70260-7