Prognostic Value of Lymphoma-specific S-Phase Fraction Compared with that of Other Cell Proliferation Markers

The proliferation-associated antigens Ki67 (immunohistochemistry) and proliferative cell nuclear antigen (PCNA) (immunohistochemistry and immunoblotting) were analysed together with DNA synthesis (3H-thymidine incorporation) and cell-cycle distribution (tumour-specific S-phase fraction determined by...

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Veröffentlicht in:	Acta oncologica 1999, Vol.38 (4), p.495-503
1. Verfasser:	Harald Holte, Zhenhe Suo, Erlend B. Smeland, Stein Kvaløy, Ruth Langholm, Trond Stokke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor Cell Division Chemical Fractionation Hematologic and hematopoietic diseases Humans Immunoblotting Immunohistochemistry Ki-67 Antigen - analysis Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - immunology Lymphoma, Non-Hodgkin - mortality Lymphoma, Non-Hodgkin - pathology Medical sciences Middle Aged Prognosis Proliferating Cell Nuclear Antigen - analysis Retrospective Studies S Phase Survival Rate
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Zusammenfassung:	The proliferation-associated antigens Ki67 (immunohistochemistry) and proliferative cell nuclear antigen (PCNA) (immunohistochemistry and immunoblotting) were analysed together with DNA synthesis (3H-thymidine incorporation) and cell-cycle distribution (tumour-specific S-phase fraction determined by flow cytometry) in lymph node suspensions from 63 patients with newly diagnosed B-Cell non-Hodgkin's lymphomas. Details of clinical parameters, treatment and patient outcome were available for all patients, and retrospectively analysed. Of the proliferation-associated parameters, only high S-phase fraction (p
ISSN:	0284-186X 1651-226X
DOI:	10.1080/028418699432040