Dextran-specific IgG response in hypersensitivity reactions to measles-mumps-rubella vaccine

[...]hypersensitivity reactions to this vaccine have been reported by various authors.1,2 In the past, allergic reactions were attributed to egg proteins. Bound antibodies were detected with a europium-labeled anti-human IgG, IgE, or IgM antiserum (PerkinElmer). Because of the high prevalence of dextran-reactive antibodies in healthy individuals, we also analyzed the sera of 11 age- and sex- matched control subjects referred to our center for consultancy because of previous adverse reactions in temporal relationship with other vaccine administrations; also tested was a group of 10 healthy donors who had never received Morupar, along with 4 children previously vaccinated with Morupar with no history of adverse reactions.