Effects of intensive lipid lowering by low-density lipoprotein apheresis on regression of coronary atherosclerosis in patients with familial hypercholesterolemia: Japan Low-density Lipoprotein Apheresis Coronary Atherosclerosis Prospective Study (L-CAPS)

Effects of intensive lipid lowering by low-density lipoprotein apheresis on regression of coronary atherosclerosis in patients with familial hypercholesterolemia: Japan Low-density Lipoprotein Apheresis Coronary Atherosclerosis Prospective Study (L-CAPS)

Twenty-five heterozygous familial hypercholesterolemic patients treated with LDL-apheresis and drugs and 11 patients treated with drugs underwent follow-up angiography 2.3 years later. One-hundred thirteen lesions were measured by quantitative angiography. Mean LDL-cholesterol levels during the tria...

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Veröffentlicht in:Atherosclerosis 1999-06, Vol.144 (2), p.409-417
Hauptverfasser: Nishimura, Shigeyuki, Sekiguchi, Morie, Kano, Tatsuji, Ishiwata, Sugao, Nagasaki, Fumihiko, Nishide, Toshio, Okimoto, Takao, Kutsumi, Yasunori, Kuwabara, Yoichi, Takatsu, Fumimaro, Nishikawa, Hideo, Daida, Hiroyuki, Yamaguchi, Hiroshi
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Biological and medical sciences
Blood Component Removal
Cardiology. Vascular system
Cholesterol, Dietary - administration & dosage
Cholesterol, LDL - blood
Combined Modality Therapy
Coronary Angiography
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - genetics
Coronary Artery Disease - therapy
Coronary heart disease
Diet, Fat-Restricted
Female
Heart
Heterozygote
Heterozygous familial hypercholesterolemia
Humans
Hyperlipoproteinemia Type II - blood
Hyperlipoproteinemia Type II - genetics
Hyperlipoproteinemia Type II - therapy
Hypolipidemic Agents - administration & dosage
LDL-apheresis
Lipoproteins, LDL - blood
Male
Medical sciences
Middle Aged
Prospective Studies
Regression of coronary lesions
Treatment Outcome
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Zusammenfassung:Twenty-five heterozygous familial hypercholesterolemic patients treated with LDL-apheresis and drugs and 11 patients treated with drugs underwent follow-up angiography 2.3 years later. One-hundred thirteen lesions were measured by quantitative angiography. Mean LDL-cholesterol levels during the trial were 140±34 mg/dl in the apheresis group and 170±58 mg/dl ( P
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(98)00328-1