Persistent activation of calcium-activated and calcium-independent protein kinase C in response to electrical afterdischarge from peptidergic neurons of Aplysia

Persistent activation of calcium-activated and calcium-independent protein kinase C in response to electrical afterdischarge from peptidergic neurons of Aplysia

The purpose of this work was to investigate the effects of electrical afterdischarge on protein kinase C (PKC) activity from bag cell neurons (BCNs) of Aplysia. Bilateral clusters of BCNs were divided: one cluster was stimulated to afterdischarge, the other was a control. Clusters were processed for...

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Veröffentlicht in:Brain research 1999-07, Vol.834 (1), p.211-213
Hauptverfasser: Wayne, Nancy L, Lee, Wenjau, Kim, Yun J
Format: Artikel
Sprache:eng
Schlagworte:
Action potential
Animals
Aplysia
Aplysia - physiology
Bag cell neuron
bag cell neurons
Biochemistry. Physiology. Immunology
Biological and medical sciences
Calcium
Calcium - physiology
Electric Stimulation
Electrophysiology
Enzyme Activation
Fundamental and applied biological sciences. Psychology
Invertebrates
Marine
Mollusca
Neuroendocrine
Neurons - physiology
Neuropeptides - physiology
Physiology. Development
Protein kinase C
Protein Kinase C - metabolism
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Zusammenfassung:The purpose of this work was to investigate the effects of electrical afterdischarge on protein kinase C (PKC) activity from bag cell neurons (BCNs) of Aplysia. Bilateral clusters of BCNs were divided: one cluster was stimulated to afterdischarge, the other was a control. Clusters were processed for PKC activity assay 5–120 min after electrical stimulation. Afterdischarge triggered a rapid and persistent increase in both calcium-activated and calcium-independent PKC activity.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(99)01594-2