Catalytic asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides using homogeneous chiral nickel-bisphosphine complexes through DKR

Catalytic asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides using homogeneous chiral nickel-bisphosphine complexes through DKR

Homogeneous chiral nickel-bisphosphine complexes catalyze the asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides through dynamic kinetic resolution to efficiently afford anti-beta-hydroxy-alpha-amino esters with high diastereo- and enantioselectivities.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2008-01 (46), p.6206-6208
Hauptverfasser: Hamada, Yasumasa, Koseki, Yu, Fujii, Takefumi, Maeda, Tsukuru, Hibino, Takuya, Makino, Kazuishi
Format: Artikel
Sprache:eng
Schlagworte:
Amines - chemistry
Amino Acids - chemistry
Catalysis
Esterification
Hydrochloric Acid - chemistry
Hydrogen - chemistry
Kinetics
Ligands
Molecular Structure
Nickel - chemistry
Phosphines - chemistry
Solvents
Stereoisomerism
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Beschreibung
Zusammenfassung:Homogeneous chiral nickel-bisphosphine complexes catalyze the asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides through dynamic kinetic resolution to efficiently afford anti-beta-hydroxy-alpha-amino esters with high diastereo- and enantioselectivities.
ISSN:1359-7345
1364-548X
DOI:10.1039/b816524f