Synthesis and Potential Muscarinic Receptor Binding and Antioxidant Properties of 3-(Thiadiazolyl)pyridine 1-Oxide Compounds
The synthesis of two different series of 3‐(thiadiazolyl)pyridine 1‐oxides containing 1,2,5‐ and 1,2,4‐thiadiazole moiety respectively is described. The potential muscarinic receptor binding together with the antioxidant properties of the new compounds were evaluated.
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| Veröffentlicht in: | Archiv der Pharmazie (Weinheim) 1999-06, Vol.332 (6), p.191-194 |
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| container_issue | 6 |
| container_start_page | 191 |
| container_title | Archiv der Pharmazie (Weinheim) |
| container_volume | 332 |
| creator | Martinez, Ana Alonso, Diana Castro, Ana Arán, Vicente J. Cardelús, Ignasi Baños, Josep E. Badia, Albert |
| description | The synthesis of two different series of 3‐(thiadiazolyl)pyridine 1‐oxides containing 1,2,5‐ and 1,2,4‐thiadiazole moiety respectively is described. The potential muscarinic receptor binding together with the antioxidant properties of the new compounds were evaluated. |
| doi_str_mv | 10.1002/(SICI)1521-4184(19996)332:6<191::AID-ARDP191>3.0.CO;2-X |
| format | Article |
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The potential muscarinic receptor binding together with the antioxidant properties of the new compounds were evaluated.</description><identifier>ISSN: 0365-6233</identifier><identifier>EISSN: 1521-4184</identifier><identifier>DOI: 10.1002/(SICI)1521-4184(19996)332:6<191::AID-ARDP191>3.0.CO;2-X</identifier><identifier>PMID: 10399487</identifier><identifier>CODEN: ARPMAS</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag GmbH</publisher><subject>Alzheimer Disease - drug therapy ; Alzheimer's disease ; antioxidants ; Antioxidants - chemical synthesis ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Biological and medical sciences ; Cholinergic system ; Medical sciences ; muscarinic agonist ; Muscarinic Agonists - chemical synthesis ; Muscarinic Agonists - metabolism ; Muscarinic Agonists - pharmacology ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. 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Pharm. Pharm. Med. Chem</addtitle><description>The synthesis of two different series of 3‐(thiadiazolyl)pyridine 1‐oxides containing 1,2,5‐ and 1,2,4‐thiadiazole moiety respectively is described. The potential muscarinic receptor binding together with the antioxidant properties of the new compounds were evaluated.</description><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer's disease</subject><subject>antioxidants</subject><subject>Antioxidants - chemical synthesis</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cholinergic system</subject><subject>Medical sciences</subject><subject>muscarinic agonist</subject><subject>Muscarinic Agonists - chemical synthesis</subject><subject>Muscarinic Agonists - metabolism</subject><subject>Muscarinic Agonists - pharmacology</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>pyridine N-oxides</subject><subject>Receptors, Muscarinic - metabolism</subject><subject>Thiadiazoles</subject><subject>Thiadiazoles - chemical synthesis</subject><subject>Thiadiazoles - metabolism</subject><subject>Thiadiazoles - pharmacology</subject><issn>0365-6233</issn><issn>1521-4184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFu0zAUhiMEYmXwCigXCLUXKbZP4sQFgUoKo9KgVTu0iZsjN3Y2Q5oEOxUr4uFx1zKQQOLKcfSdX7_PFwSvKBlSQtiz_nKaTwc0YTSKaRb3qRCCDwDYiL-ggo5G4-kkGi8mc395CUMyzGfPWXRxJ-jdztwNegR4EnEGcBQ8cO4zIQQIS-4HR5SAEHGW9oIfy23dXWlnXChrFc6bTtedkVX4fuMKaU1tinChC912jQ1fm1qZ-vKGHHusuTZK1l04t02rbWe0C5syhKh_dmWkMvJ7U22rQbu1xo_pkEYzP6DDvFm3zaZW7mFwr5SV048O53Hw8e2bs_xddDo7mebj06iIIaX-BVKsAAhXghWpLBWHdFUmKmOKJAKUSjOepiXERMU6TkpdJAWoOONFIlYCAI6Dp_vc1jZfN9p1uDau0FUla91sHHKRZTHjiQfP92BhG-esLrG1Zi3tFinBnRjEnRjcLRl3S8YbMejFIPffFNGLwYMYBCSYz5DhhU9-fKiwWa21-iN3b8IDTw6A9IuvSivrwrjfXMYZgx32aY99M5Xe_lXvP-3-Xe7XLx8e7cON6_T1bbi0X5CnkCZ4_uEEM5ouyDKfYAw_ARVtxtg</recordid><startdate>199906</startdate><enddate>199906</enddate><creator>Martinez, Ana</creator><creator>Alonso, Diana</creator><creator>Castro, Ana</creator><creator>Arán, Vicente J.</creator><creator>Cardelús, Ignasi</creator><creator>Baños, Josep E.</creator><creator>Badia, Albert</creator><general>WILEY-VCH Verlag GmbH</general><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199906</creationdate><title>Synthesis and Potential Muscarinic Receptor Binding and Antioxidant Properties of 3-(Thiadiazolyl)pyridine 1-Oxide Compounds</title><author>Martinez, Ana ; Alonso, Diana ; Castro, Ana ; Arán, Vicente J. ; Cardelús, Ignasi ; Baños, Josep E. ; Badia, Albert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4371-62a9b3306d92c7afd637bf5d82d0593dd78677f340d4e45fec5c3d486c59b9333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Alzheimer Disease - drug therapy</topic><topic>Alzheimer's disease</topic><topic>antioxidants</topic><topic>Antioxidants - chemical synthesis</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cholinergic system</topic><topic>Medical sciences</topic><topic>muscarinic agonist</topic><topic>Muscarinic Agonists - chemical synthesis</topic><topic>Muscarinic Agonists - metabolism</topic><topic>Muscarinic Agonists - pharmacology</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>pyridine N-oxides</topic><topic>Receptors, Muscarinic - metabolism</topic><topic>Thiadiazoles</topic><topic>Thiadiazoles - chemical synthesis</topic><topic>Thiadiazoles - metabolism</topic><topic>Thiadiazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinez, Ana</creatorcontrib><creatorcontrib>Alonso, Diana</creatorcontrib><creatorcontrib>Castro, Ana</creatorcontrib><creatorcontrib>Arán, Vicente J.</creatorcontrib><creatorcontrib>Cardelús, Ignasi</creatorcontrib><creatorcontrib>Baños, Josep E.</creatorcontrib><creatorcontrib>Badia, Albert</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archiv der Pharmazie (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez, Ana</au><au>Alonso, Diana</au><au>Castro, Ana</au><au>Arán, Vicente J.</au><au>Cardelús, Ignasi</au><au>Baños, Josep E.</au><au>Badia, Albert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Potential Muscarinic Receptor Binding and Antioxidant Properties of 3-(Thiadiazolyl)pyridine 1-Oxide Compounds</atitle><jtitle>Archiv der Pharmazie (Weinheim)</jtitle><addtitle>Arch. 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| fulltext | fulltext |
| identifier | ISSN: 0365-6233 |
| ispartof | Archiv der Pharmazie (Weinheim), 1999-06, Vol.332 (6), p.191-194 |
| issn | 0365-6233 1521-4184 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Alzheimer Disease - drug therapy Alzheimer's disease antioxidants Antioxidants - chemical synthesis Antioxidants - metabolism Antioxidants - pharmacology Biological and medical sciences Cholinergic system Medical sciences muscarinic agonist Muscarinic Agonists - chemical synthesis Muscarinic Agonists - metabolism Muscarinic Agonists - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments pyridine N-oxides Receptors, Muscarinic - metabolism Thiadiazoles Thiadiazoles - chemical synthesis Thiadiazoles - metabolism Thiadiazoles - pharmacology |
| title | Synthesis and Potential Muscarinic Receptor Binding and Antioxidant Properties of 3-(Thiadiazolyl)pyridine 1-Oxide Compounds |
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