Synthesis and Potential Muscarinic Receptor Binding and Antioxidant Properties of 3-(Thiadiazolyl)pyridine 1-Oxide Compounds

The synthesis of two different series of 3‐(thiadiazolyl)pyridine 1‐oxides containing 1,2,5‐ and 1,2,4‐thiadiazole moiety respectively is described. The potential muscarinic receptor binding together with the antioxidant properties of the new compounds were evaluated.

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Bibliographische Detailangaben
Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 1999-06, Vol.332 (6), p.191-194
Hauptverfasser:	Martinez, Ana, Alonso, Diana, Castro, Ana, Arán, Vicente J., Cardelús, Ignasi, Baños, Josep E., Badia, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer's disease antioxidants Antioxidants - chemical synthesis Antioxidants - metabolism Antioxidants - pharmacology Biological and medical sciences Cholinergic system Medical sciences muscarinic agonist Muscarinic Agonists - chemical synthesis Muscarinic Agonists - metabolism Muscarinic Agonists - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments pyridine N-oxides Receptors, Muscarinic - metabolism Thiadiazoles Thiadiazoles - chemical synthesis Thiadiazoles - metabolism Thiadiazoles - pharmacology
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Beschreibung
Zusammenfassung:	The synthesis of two different series of 3‐(thiadiazolyl)pyridine 1‐oxides containing 1,2,5‐ and 1,2,4‐thiadiazole moiety respectively is described. The potential muscarinic receptor binding together with the antioxidant properties of the new compounds were evaluated.
ISSN:	0365-6233 1521-4184
DOI:	10.1002/(SICI)1521-4184(19996)332:6<191::AID-ARDP191>3.0.CO;2-X