Cellular expression of a leech netrin suggests roles in the formation of longitudinal nerve tracts and in regional innervation of peripheral targets

Netrins are secreted, diffusible proteins that direct axonal growth. To study the functions of netrins in the relatively simple and easily accessible nervous system of the leech Hirudo medicinalis, we have cloned a leech netrin and have characterized its expression during embryogenesis. By probing a...

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Veröffentlicht in:	Journal of neurobiology 1999-07, Vol.40 (1), p.103-115
Hauptverfasser:	Gan, Wen‐Biao, Wong, Victoria Y., Phillips, Aloysius, Ma, Charles, Gershon, Timothy R., Macagno, Eduardo R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Chickens Cloning, Molecular Embryo, Nonmammalian - metabolism Evolution, Molecular Ganglia, Invertebrate - embryology Ganglia, Invertebrate - metabolism Gene Expression Regulation, Developmental Gene Library Humans In Situ Hybridization Leeches - embryology Leeches - genetics Molecular Sequence Data Nerve Growth Factors - biosynthesis Nerve Growth Factors - chemistry Nerve Growth Factors - genetics Netrin-1 Neural Pathways - embryology Neural Pathways - metabolism Neurons - metabolism Phylogeny Sequence Alignment Sequence Homology, Amino Acid Tumor Suppressor Proteins
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