Inhibition of aromatase activity by flavonoids
In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, wit...
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| Veröffentlicht in: | Archives of pharmacal research 1999-06, Vol.22 (3), p.309-312 |
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| container_title | Archives of pharmacal research |
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| creator | Jeong, Hyeh -Jean Shin, Young Geun Kim, Il -Hyuk Pezzuto, John M |
| description | In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC₅₀: 0.9 μg/mL), chrysin (IC₅₀: 1.1 μg/mL), and hesperetin (IC₅₀: 1.0 μg/mL). |
| doi_str_mv | 10.1007/BF02976369 |
| format | Article |
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Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC₅₀: 0.9 μg/mL), chrysin (IC₅₀: 1.1 μg/mL), and hesperetin (IC₅₀: 1.0 μg/mL).</description><identifier>ISSN: 0253-6269</identifier><identifier>EISSN: 1976-3786</identifier><identifier>DOI: 10.1007/BF02976369</identifier><identifier>PMID: 10403137</identifier><language>eng</language><publisher>Korea (South): Pharmaceutical Society of Korea</publisher><subject>apigenin ; aromatase ; Aromatase - metabolism ; chemoprevention ; Dose-Response Relationship, Drug ; Drug Evaluation ; Female ; Flavonoids - pharmacology ; hesperetin ; Humans ; inhibitory concentration 50 ; Microsomes - enzymology ; placenta ; Placenta - enzymology ; Pregnancy ; Time Factors</subject><ispartof>Archives of pharmacal research, 1999-06, Vol.22 (3), p.309-312</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-6a2a110da497f1da0457ff64f81f022773745f21e81905ed7425895a3ce9ebc43</citedby><cites>FETCH-LOGICAL-c307t-6a2a110da497f1da0457ff64f81f022773745f21e81905ed7425895a3ce9ebc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10403137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Hyeh -Jean</creatorcontrib><creatorcontrib>Shin, Young Geun</creatorcontrib><creatorcontrib>Kim, Il -Hyuk</creatorcontrib><creatorcontrib>Pezzuto, John M</creatorcontrib><title>Inhibition of aromatase activity by flavonoids</title><title>Archives of pharmacal research</title><addtitle>Arch Pharm Res</addtitle><description>In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC₅₀: 0.9 μg/mL), chrysin (IC₅₀: 1.1 μg/mL), and hesperetin (IC₅₀: 1.0 μg/mL).</description><subject>apigenin</subject><subject>aromatase</subject><subject>Aromatase - metabolism</subject><subject>chemoprevention</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Evaluation</subject><subject>Female</subject><subject>Flavonoids - pharmacology</subject><subject>hesperetin</subject><subject>Humans</subject><subject>inhibitory concentration 50</subject><subject>Microsomes - enzymology</subject><subject>placenta</subject><subject>Placenta - enzymology</subject><subject>Pregnancy</subject><subject>Time Factors</subject><issn>0253-6269</issn><issn>1976-3786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0L1OwzAUhmELgWj5WbgAyMSAlHJsx3Y8QkWhUiUG6GydJDYYJXGJ00q9e4JSCaZzhkff8BJyRWFGAdT94wKYVpJLfUSmdPhSrnJ5TKbABE8lk3pCzmL8AuBSCHFKJhQy4JSrKZkt209f-N6HNgkuwS402GO0CZa93_l-nxT7xNW4C23wVbwgJw7raC8P95ysF0_v85d09fq8nD-s0pKD6lOJDCmFCjOtHK0QMqGck5nLqQPGlOIqE45Rm1MNwlYqYyLXAnlptS3KjJ-T23F304XvrY29aXwsbV1ja8M2GqnzHBhlA7wbYdmFGDvrzKbzDXZ7Q8H81jF_dQZ8fVjdFo2t_tExxwBuRuAwGPzofDTrNwZUAgDVHBj_AXngZmc</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Jeong, Hyeh -Jean</creator><creator>Shin, Young Geun</creator><creator>Kim, Il -Hyuk</creator><creator>Pezzuto, John M</creator><general>Pharmaceutical Society of Korea</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Inhibition of aromatase activity by flavonoids</title><author>Jeong, Hyeh -Jean ; Shin, Young Geun ; Kim, Il -Hyuk ; Pezzuto, John M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-6a2a110da497f1da0457ff64f81f022773745f21e81905ed7425895a3ce9ebc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>apigenin</topic><topic>aromatase</topic><topic>Aromatase - metabolism</topic><topic>chemoprevention</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Evaluation</topic><topic>Female</topic><topic>Flavonoids - pharmacology</topic><topic>hesperetin</topic><topic>Humans</topic><topic>inhibitory concentration 50</topic><topic>Microsomes - enzymology</topic><topic>placenta</topic><topic>Placenta - enzymology</topic><topic>Pregnancy</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Hyeh -Jean</creatorcontrib><creatorcontrib>Shin, Young Geun</creatorcontrib><creatorcontrib>Kim, Il -Hyuk</creatorcontrib><creatorcontrib>Pezzuto, John M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of pharmacal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Hyeh -Jean</au><au>Shin, Young Geun</au><au>Kim, Il -Hyuk</au><au>Pezzuto, John M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of aromatase activity by flavonoids</atitle><jtitle>Archives of pharmacal research</jtitle><addtitle>Arch Pharm Res</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>22</volume><issue>3</issue><spage>309</spage><epage>312</epage><pages>309-312</pages><issn>0253-6269</issn><eissn>1976-3786</eissn><abstract>In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC₅₀: 0.9 μg/mL), chrysin (IC₅₀: 1.1 μg/mL), and hesperetin (IC₅₀: 1.0 μg/mL).</abstract><cop>Korea (South)</cop><pub>Pharmaceutical Society of Korea</pub><pmid>10403137</pmid><doi>10.1007/BF02976369</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0253-6269 |
| ispartof | Archives of pharmacal research, 1999-06, Vol.22 (3), p.309-312 |
| issn | 0253-6269 1976-3786 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69880212 |
| source | MEDLINE; Springer Online Journals Complete |
| subjects | apigenin aromatase Aromatase - metabolism chemoprevention Dose-Response Relationship, Drug Drug Evaluation Female Flavonoids - pharmacology hesperetin Humans inhibitory concentration 50 Microsomes - enzymology placenta Placenta - enzymology Pregnancy Time Factors |
| title | Inhibition of aromatase activity by flavonoids |
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