Inhibition of aromatase activity by flavonoids

In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, wit...

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Veröffentlicht in:	Archives of pharmacal research 1999-06, Vol.22 (3), p.309-312
Hauptverfasser:	Jeong, Hyeh -Jean, Shin, Young Geun, Kim, Il -Hyuk, Pezzuto, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	apigenin aromatase Aromatase - metabolism chemoprevention Dose-Response Relationship, Drug Drug Evaluation Female Flavonoids - pharmacology hesperetin Humans inhibitory concentration 50 Microsomes - enzymology placenta Placenta - enzymology Pregnancy Time Factors
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Beschreibung
Zusammenfassung:	In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC₅₀: 0.9 μg/mL), chrysin (IC₅₀: 1.1 μg/mL), and hesperetin (IC₅₀: 1.0 μg/mL).
ISSN:	0253-6269 1976-3786
DOI:	10.1007/BF02976369