20-Hydroxyecdysone as a human lymphocyte and neutrophil modulator: in vitro evaluation

20-hydroxyecdysone (1 micromolar) was found to activate in vitro T-cell CD2 presentation, which is suppressed both in secondary immunodeficient persons and pharmacologically by increasing intracellular cAMP levels. The compound was found to act like a synthetic psycho-immunomodulator 1-oxy-4-oxoadam...

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Veröffentlicht in:	Archives of insect biochemistry and physiology 1999, Vol.41 (3), p.156-161
Hauptverfasser:	Trenin, D.S, Volodin, V.V
Format:	Artikel
Sprache:	eng
Schlagworte:	1-oxy-4-oxoadamantane 20-hydroxyecdysone Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - pharmacology antioxidants CD2 Antigens - biosynthesis CD2-presentation defense mechanisms ecdysterone Ecdysterone - chemistry Ecdysterone - pharmacology Humans immune response immunomodulators immunostimulation in vitro In Vitro Techniques levamisol levamisole Molecular Structure neutrophils Neutrophils - drug effects Neutrophils - immunology respiratory burst rosette formation T-lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - immunology
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Zusammenfassung:	20-hydroxyecdysone (1 micromolar) was found to activate in vitro T-cell CD2 presentation, which is suppressed both in secondary immunodeficient persons and pharmacologically by increasing intracellular cAMP levels. The compound was found to act like a synthetic psycho-immunomodulator 1-oxy-4-oxoadamantane (1 micromolar) and to exceed the effects of the thymomimetic agent levamisol (1 micromolar). In addition, 20-hydroxyecdysone (1 micromolar) was also revealed to modulate- the fluoride-stimulated respiratory burst of human neutrophils in the same manner as water soluble antioxidants.
ISSN:	0739-4462 1520-6327
DOI:	10.1002/(SICI)1520-6327(1999)41:3<156::AID-ARCH7>3.0.CO;2-Q