Limited argon laser peripheral iridoplasty as immediate treatment for an acute attack of primary angle closure glaucoma: A preliminary study

Purpose To study the efficacy and safety of limited (180°) argon laser peripheral iridoplasty (ALPI) as a first-line treatment for acute primary angle closure glaucoma (PACG) without the use of systemic anti-glaucomatous medications. Methods Ten consecutive patients with PACG were recruited into the study. Each patient received topical pilocarpine (4%) and timolol (0.5%), and immediate limited ALPI as primary treatment. The intraocular pressures at 15, 30 and 60 min after ALPI were documented by Goldmann applanation tonometry. Results The mean intraocular pressure (IOP) of this group of patients was reduced from 57.9 ± 10.6 mmHg to 39.0 ± 10.9 mmHg at 15 min, 28.3 ± 9.1 mmHg at 30 min and 20.4 ± 9.0 mmHg at 60 min after ALPI. No complications were encountered. In 8 of the 10 patients the corneal oedema cleared 1 h after ALPI. In the remaining 2 patients the corneal oedema cleared 2 h after ALPI. Conclusion Immediate limited ALPI, without adjunctive systemic anti-glaucomatous medications, appeared to be effective and safe in controlling the IOP in treating acute PACG with a duration of attack ≤ 48 h. It may be as effective as 360° ALPI, and therefore has a role in those patients in whom 360° treatment is not possible.