Mathemycin B, a New Antifungal Macrolactone from Actinomycete Species HIL Y-8620959

A new macrocyclic lactone antibiotic mathemycin B (1) was isolated from the fermentation broth of an Actinomycete sp. culture Y-8620959. The structure of 1 was elucidated by high-resolution MS and interpretation of 2D NMR results. Mathemycin B is active against a variety of phytopathogenic organisms...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1999-06, Vol.62 (6), p.889-890
Hauptverfasser:	Mukhopadhyay, Triptikumar, Nadkarni, S. R, Bhat, R. G, Gupte, S. V, Ganguli, B. N, Petry, S, Kogler, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales Actinomycetales - chemistry Actinomycetes Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology antibiotics Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - isolation & purification Antifungal Agents - pharmacology antifungal properties Applied microbiology Biological and medical sciences chemical composition chemical structure Fermentation Fundamental and applied biological sciences. Psychology Fungi - drug effects lactone antibiotics lactones Macrolides Magnetic Resonance Spectroscopy Mass Spectrometry mathemycin B Microbial Sensitivity Tests Microbiology plant pathogenic fungi spectral analysis
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Zusammenfassung:	A new macrocyclic lactone antibiotic mathemycin B (1) was isolated from the fermentation broth of an Actinomycete sp. culture Y-8620959. The structure of 1 was elucidated by high-resolution MS and interpretation of 2D NMR results. Mathemycin B is active against a variety of phytopathogenic organisms.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np980369q