AKT and Oxidative Stress Team Up to Kill Cancer Cells
AKT, a protein kinase frequently hyperactivated in cancer, plays an important role in cell survival and contributes to tumor cell resistance to cytotoxic therapies. A new study in this issue of Cancer Cell shows that AKT also induces the accumulation of oxygen radicals, which can be exploited to sel...
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| Veröffentlicht in: | Cancer cell 2008-12, Vol.14 (6), p.427-429 |
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| container_end_page | 429 |
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| container_issue | 6 |
| container_start_page | 427 |
| container_title | Cancer cell |
| container_volume | 14 |
| creator | Dolado, Ignacio Nebreda, Angel R. |
| description | AKT, a protein kinase frequently hyperactivated in cancer, plays an important role in cell survival and contributes to tumor cell resistance to cytotoxic therapies. A new study in this issue of
Cancer Cell shows that AKT also induces the accumulation of oxygen radicals, which can be exploited to selectively kill cancer cells containing high levels of AKT activity. |
| doi_str_mv | 10.1016/j.ccr.2008.11.006 |
| format | Article |
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| ispartof | Cancer cell, 2008-12, Vol.14 (6), p.427-429 |
| issn | 1535-6108 1878-3686 |
| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Apoptosis Cell Survival Gene Expression Regulation, Neoplastic Humans Models, Biological Neoplasms - metabolism Oxidative Stress Proto-Oncogene Proteins c-akt - metabolism Signal Transduction |
| title | AKT and Oxidative Stress Team Up to Kill Cancer Cells |
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