AKT and Oxidative Stress Team Up to Kill Cancer Cells

AKT and Oxidative Stress Team Up to Kill Cancer Cells

AKT, a protein kinase frequently hyperactivated in cancer, plays an important role in cell survival and contributes to tumor cell resistance to cytotoxic therapies. A new study in this issue of Cancer Cell shows that AKT also induces the accumulation of oxygen radicals, which can be exploited to sel...

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Veröffentlicht in:Cancer cell 2008-12, Vol.14 (6), p.427-429
Hauptverfasser: Dolado, Ignacio, Nebreda, Angel R.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apoptosis
Cell Survival
Gene Expression Regulation, Neoplastic
Humans
Models, Biological
Neoplasms - metabolism
Oxidative Stress
Proto-Oncogene Proteins c-akt - metabolism
Signal Transduction
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Zusammenfassung:AKT, a protein kinase frequently hyperactivated in cancer, plays an important role in cell survival and contributes to tumor cell resistance to cytotoxic therapies. A new study in this issue of Cancer Cell shows that AKT also induces the accumulation of oxygen radicals, which can be exploited to selectively kill cancer cells containing high levels of AKT activity.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2008.11.006