Prevalence, Clinical Presentations and Complications among Hospitalized Children with Influenza Pneumonia

Viral respiratory tract infections are a major cause of hospitalization in children. Influenza is common but often not laboratory proven. We report a prospective study of children admitted with a clinical diagnosis of pneumonia. Infants and children (ages 1 month - 15 years) who were hospitalized wi...

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Veröffentlicht in:Japanese Journal of Infectious Diseases 2008/11/28, Vol.61(6), pp.446-449
Hauptverfasser: Samransamruajkit, Rujipat, Hiranrat, Titikul, Chieochansin, Thaweesak, Sritippayawan, Suchada, Deerojanawong, Jitladda, Prapphal, Nuanchan, Poovorawan, Yong
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Sprache:eng
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Zusammenfassung:Viral respiratory tract infections are a major cause of hospitalization in children. Influenza is common but often not laboratory proven. We report a prospective study of children admitted with a clinical diagnosis of pneumonia. Infants and children (ages 1 month - 15 years) who were hospitalized with community-acquired pneumonia were enrolled in the study. Their nasopharyngeal aspirated samples were analyzed for common respiratory viruses, including influenza virus, by reverse transcription-polymerase chain reaction (RT-PCR) or PCR. Out of 257 patients, we identified 127 (49.4%) cases with respiratory viruses, and influenza was found in 32 of these cases (12.5%). Other common respiratory viruses included respiratory syncytial virus in 42 (16.3%), human metapneumovirus in 24 (9.3%), adenovirus in 17 (6.6%) and parainfluenza virus in 12 (4.7%). The median age of the influenza group was 2 years and 3 months, and 27 (84%) of children in this group were under the age of 5. Asthma was the most common co-morbidity (4/32, 12.5%). Common clinical presentations were fever and cough (100%) with crepitations (90%). The median length of hospitalization was 6 days. Three patients developed respiratory failure, with one mortality (3.1%). One child developed infection-associated hemophagocytic syndrome. Our study demonstrated that young children had a high risk of hospitalization due to influenza pneumonia, which contributed to a significant morbidity.
ISSN:1344-6304
1884-2836
DOI:10.7883/yoken.JJID.2008.446