Biotransformation of the diperpenoid, isosteviol, by Aspergillus niger, Penicillium chrysogenum and Rhizopus arrhizus

The biotransformation of isosteviol ( ent-16-ketobeyeran-19-oic acid) by three fungi is described. Aspergillus niger produced the 7β-OH derivative, ent-7α-hydroxy-16-ketobeyeran-19-oic, and the 1α,7β-diOH derivative, ent-1β,7α-dihydroxy-16-ketobeyeran-19-oic acid. The 17-OH compound, ent-17-hydroxy-...

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Veröffentlicht in:	Phytochemistry (Oxford) 1999-07, Vol.51 (6), p.737-741
Hauptverfasser:	de Oliveira, Brás H, dos Santos, Márcia C, Leal, Paulo C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus niger Aspergillus niger - metabolism Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformation Diterpenes - chemistry Diterpenes - pharmacokinetics Diterpenes, Kaurane Diterpenoid Fundamental and applied biological sciences. Psychology Isosteviol Magnetic Resonance Spectroscopy Mass Spectrometry Methods. Procedures. Technologies Molecular Structure Penicillium chrysogenum Penicillium chrysogenum - metabolism Rhizopus - metabolism Rhizopus arrhizus Spectrophotometry, Infrared
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Zusammenfassung:	The biotransformation of isosteviol ( ent-16-ketobeyeran-19-oic acid) by three fungi is described. Aspergillus niger produced the 7β-OH derivative, ent-7α-hydroxy-16-ketobeyeran-19-oic, and the 1α,7β-diOH derivative, ent-1β,7α-dihydroxy-16-ketobeyeran-19-oic acid. The 17-OH compound, ent-17-hydroxy-16-ketobeyeran-19-oic acid, was obtained with Penicillium chrysogenum. Rhizopus arrhizus produced the 7β-OH derivative, ent-7α-hydroxy-16-ketobeyeran-19-oic acid. The isolated metabolites were characterised by IR, NMR and MS.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/S0031-9422(99)00058-8