High plasma glutamate concentrations are associated with infarct growth in acute ischemic stroke

Excitotoxic and inflammatory mechanisms have been demonstrated as mediating early neurologic deterioration (END) in patients with cerebral infarction. Here we investigate whether molecular markers associated with END are related to the volume and outcome of the diffusion weighted image (DWI) lesion...

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Veröffentlicht in:	Neurology 2008-12, Vol.71 (23), p.1862-1868
Hauptverfasser:	CARSTELLANOS, M, SOBRINO, T, PEDRAZA, S, MOLDES, O, PUMAR, J. M, SILVA, Y, SERENA, J, GARCIA-GIL, M, CASTILLO, J, DAVALOS, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - blood Biological and medical sciences Cerebral Infarction - blood Cerebral Infarction - etiology Chi-Square Distribution Chromatography, High Pressure Liquid - methods Diffusion Magnetic Resonance Imaging Female Glutamic Acid - blood Humans Image Processing, Computer-Assisted Interleukin-6 - blood Linear Models Male Medical sciences Neurology Retrospective Studies Stroke - complications Time Factors Tumor Necrosis Factor-alpha - blood Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	Excitotoxic and inflammatory mechanisms have been demonstrated as mediating early neurologic deterioration (END) in patients with cerebral infarction. Here we investigate whether molecular markers associated with END are related to the volume and outcome of the diffusion weighted image (DWI) lesion in acute ischemic stroke. MRI was performed on admission and at 72 hours in 197 patients with acute hemispheric infarction of
ISSN:	0028-3878 1526-632X
DOI:	10.1212/01.wnl.0000326064.42186.7e