Effect of Ursodeoxycholic Acid on Liver Function in Children After Successful Surgery for Biliary Atresia

Although ursodeoxycholic acid has been used to treat various cholestatic liver diseases in children, few data are available about its efficacy in biliary atresia. The aim of this study was to assess the effect of ursodeoxycholic acid treatment on liver function in children who underwent successful s...

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Veröffentlicht in:	Pediatrics (Evanston) 2008-12, Vol.122 (6), p.e1236-e1241
Hauptverfasser:	Willot, Stephanie, Uhlen, Stephanie, Michaud, Laurent, Briand, Gilbert, Bonnevalle, Michel, Sfeir, Rony, Gottrand, Frederic
Format:	Artikel
Sprache:	eng
Schlagworte:	Biliary Atresia - diagnosis Biliary Atresia - drug therapy Biliary Atresia - mortality Biliary Atresia - surgery Children & youth Cholagogues and Choleretics - administration & dosage Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Infant Infant, Newborn Liver - drug effects Liver - enzymology Liver diseases Liver Function Tests Male Pediatrics Portoenterostomy, Hepatic - methods Probability Prospective Studies Severity of Illness Index Statistics, Nonparametric Studies Surgery Ursodeoxycholic Acid - administration & dosage
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Zusammenfassung:	Although ursodeoxycholic acid has been used to treat various cholestatic liver diseases in children, few data are available about its efficacy in biliary atresia. The aim of this study was to assess the effect of ursodeoxycholic acid treatment on liver function in children who underwent successful surgery for biliary atresia. We prospectively studied 16 children with biliary atresia who underwent successful portoenterostomies (postoperative conjugated bilirubin concentration:
ISSN:	0031-4005 1098-4275
DOI:	10.1542/peds.2008-0986