Specific sHLA in healthy donors and donor-specific sHLA in renal transplant patients

We studied cadaver kidney transplant recipients to determine if their serum levels of donor-specific class I sHLA correlated with graft outcome. Testing of sHLA was performed by an ELISA sandwich assay using allospecific monoclonal trapping antibodies and anti-β2-μ detecting antibody. Sufficient sHL...

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Veröffentlicht in:	Human immunology 1999-05, Vol.60 (5), p.430-434
Hauptverfasser:	Borelli, Sueli D, Ferreira, Euripedes, Oliveira, Aparecido M, Krishnaswamy, Shalini, Hiraki, Debra D, Grumet, F.Carl
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - blood Cadaver ELISA Enzyme-Linked Immunosorbent Assay Graft Rejection - diagnosis Graft Rejection - immunology Histocompatibility Antigens Class I - blood HLA-A Antigens - blood HLA-B Antigens - blood Humans Kidney Transplantation - immunology renal transplant soluble HLA soluble HLA-A2 and HLA-B7 Time Factors typing
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Beschreibung
Zusammenfassung:	We studied cadaver kidney transplant recipients to determine if their serum levels of donor-specific class I sHLA correlated with graft outcome. Testing of sHLA was performed by an ELISA sandwich assay using allospecific monoclonal trapping antibodies and anti-β2-μ detecting antibody. Sufficient sHLA sensitivity (
ISSN:	0198-8859 1879-1166
DOI:	10.1016/S0198-8859(99)00012-9